Evaluation of serum interleukin-6 levels in hepatocellular carcinoma patients: A systematic review and meta-analysis

Shakiba, E. and Ramezani, M. and Sadeghi, M. (2018) Evaluation of serum interleukin-6 levels in hepatocellular carcinoma patients: A systematic review and meta-analysis. Clinical and Experimental Hepatology, 4 (3). pp. 182-190.

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Abstract

Aim of the study: This meta-analysis evaluated serum interleukin-6 (IL-6) levels in hepatocellular carcinoma (HCC) patients compared with healthy controls and hepatitis and cirrhotic patients. Material and methods: The three databases PubMed, Scopus, and Web of Science were searched for assessment of IL-6 levels in HCC patients (without cirrhosis and hepatitis) compared with healthy controls (without HCC, cirrhosis and hepatitis) and the studies were selected based on inclusion and exclusion criteria. A random-effect meta-analysis was performed with RevMan 5.3 software, using mean difference (MD) and 95 confidence intervals (CIs). Results: Out of 503 studies searched in databases, 18 studies were included in the meta-analysis. The pooled analysis with continuous data demonstrated that the IL-6 level in HCC patients was significantly higher than that in healthy controls (MD = 12.44; 95 CI: 9.02-15.85; p < 0.00001). Also, the pooled analysis demonstrated that the IL-6 levels in cirrhotic patients (MD = –6.98; 95 CI: –12.91-1.05; p < 0.02) and patients with hepatitis (MD = –8.43; 95 CI: –11.91-4.95; p < 0.00001) were significantly lower than the level in HCC patients, and the subgroup analyses had high heterogeneity. Conclusions: The elevated IL-6 levels in HCC patients compared with hepatitis and cirrhosis patients and healthy controls may show a significant association of this cytokine with increased risk of HCC and its potential as a diagnostic marker for HCC in future diagnostic and therapeutic strategies. © 2018 Termedia Publishing House Ltd.. All Rights Reserved.

Item Type: Article
Additional Information: Cited By :4 Export Date: 16 February 2020 Correspondence Address: Sadeghi, M.; Medical Biology Research Center, Kermanshah University of Medical SciencesIran; email: sadeghimbrc@yahoo.com
Uncontrolled Keywords: Hepatocellular carcinoma Interleukin-6 Serum interleukin 6 Article cancer diagnosis cancer risk hepatitis human lifestyle liver cell carcinoma liver cirrhosis protein blood level systematic review
Subjects: WI Digestive System
QU Biochemistry
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 04 May 2020 07:32
Last Modified: 04 May 2020 07:32
URI: http://eprints.mums.ac.ir/id/eprint/17525

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