Vitreous changes after intravitreal bevacizumab monotherapy for retinopathy of prematurity: A case series

Shoeibi, N. and Hosseini, S. M. and Banaee, T. and Ansari-Astaneh, M. R. and Abrishami, M. and Ahmadieh, H. (2018) Vitreous changes after intravitreal bevacizumab monotherapy for retinopathy of prematurity: A case series. International Journal of Retina and Vitreous, 4 (1).

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Abstract

Purpose: Reporting a special clinical finding after intravitreal bevacizumab monotherapy for retinopathy of prematurity. Methods: In a retrospective case series, the clinical courses of five premature infants with similar vitreous changes after a single dose of intravitreal bevacizumab (IVB) injection without additional laser therapy were reported. Results: The mean post-conceptional age at IVB injection was 39.8 ± 2.2 (range 37-43) weeks. Localized vitreous syneresis and linear fibrotic vitreous condensation occurred 8.2 ± 2.3 weeks after IVB monotherapy in our patients (15.5 of injections). The mean last post injection visit was 61.6 ± 5.3 weeks (post-conceptional age). Further regression and complete retinal vascularization occurred in all patients. Conclusions: Thread-like vitreous condensation with localized vitreous liquefaction may be related to involutional ROP disease itself, combined to anti VEGF therapy and may be a predictor factor for further regression and retinal vascularization. The case series describes a successful response to anti-VEGF monotherapy with no further complications. © The Author(s) 2018.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Hosseini, S.M.; Eye Research Center, Mashhad University of Medical SciencesIran; email: hoseinimm@mums.ac.ir
Uncontrolled Keywords: Anti-VEGF Bevacizumab Retinopathy of prematurity Vitreous condensation Vitreous detachment vasculotropin Article B scan birth weight disease course echography human liquefaction major clinical study monotherapy newborn prematurity priority journal retina detachment retrolental fibroplasia retrospective study single drug dose treatment response vitreous body vitreous body detachment
Subjects: WW Ophthalmology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 04 May 2020 03:36
Last Modified: 04 May 2020 03:36
URI: http://eprints.mums.ac.ir/id/eprint/17536

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