Interactive involvement of hippocampal cAMP/PKA and cyclooxygenase-2 signaling pathways in spatial learning in the morris water maze

Tabrizian, K. and Hashemzaei, M. and Nasiri, A. A. and Najafi, S. and Amelinia, F. and Sanati, M. and Shamshirgaran, F. and Fanoudi, S. (2018) Interactive involvement of hippocampal cAMP/PKA and cyclooxygenase-2 signaling pathways in spatial learning in the morris water maze. Folia Neuropathologica, 56 (1). pp. 58-66.

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Abstract

Introduction: Accumulated evidence shows that the cAMP-PKA signaling pathway plays a key role in memory functions. Cyclooxygenase-2, a critical player in neuroinflammation, has been confirmed in the pathogenesis of neurodegenerative diseases. This study is aimed to assess the effect of the interaction of cAMP-PKA and cyclooxygenase pathways on spatial memory acquisition in animal models. Material and methods: In the present study, the effects of the four-day bilateral intra-hippocampal infusions of H-89 as a protein kinase AII inhibitor (10 µM/side), celecoxib (0.1 M/side) as a selective cyclooxygenase-2 inhibitor, celecoxib/ H-89 and bucladesine (10 µM/side)/celecoxib/H-89 on spatial memory acquisition in the Morris water maze were investigated. Control animals received bilateral intra-hippocampal infusions of dimethyl sulfoxide. Rats were trained for 4 days; each day included one block of four trials. Post-training probe trial tests were performed on day five. Results: A bilateral intra-hippocampal infusion of H-89 and celecoxib led to a significant impairment in spatial learning compared to the controls through a notable decrease in escape latency and traveled distance. But, combination treatment of animals with celecoxib/H-89 and bucladesine/celecoxib/H-89 could considerably reverse celecoxib and H-89-induced spatial memory acquisition impairments in the Morris water maze. Conclusions: These results indicate the probable regulatory effects of cAMP/PKA and cyclooxygenase-2 signaling pathways on spatial memory acquisition in the Morris water maze. © 2018 Termedia Publishing House Ltd. All Rights Reserved.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 CODEN: FONEE Correspondence Address: Fanoudi, S.; Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical SciencesIran; email: fanoudis921@mums.ac.ir
Uncontrolled Keywords: CAMP/PKA COX-2 Hippocampus Morris water maze Spatial memory acquisition cyclic AMP dependent protein kinase cyclooxygenase 2 bucladesine celecoxib cyclic AMP cyclooxygenase 2 inhibitor isoquinoline derivative N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide protein kinase inhibitor sulfonamide animal experiment animal model Article controlled study disease association distance perception enzyme regulation latent period learning disorder male memory memory acquisition Morris water maze test nonhuman protein protein interaction rat signal transduction spatial learning animal drug effect maze test metabolism physiology Wistar rat Animals Cyclic AMP-Dependent Protein Kinases Cyclooxygenase 2 Inhibitors Isoquinolines Maze Learning Protein Kinase Inhibitors Rats Rats, Wistar Sulfonamides
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 28 Apr 2020 08:49
Last Modified: 28 Apr 2020 08:49
URI: http://eprints.mums.ac.ir/id/eprint/17550

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