Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome: A review

Tajmohammadi, A. and Razavi, B. M. and Hosseinzadeh, H. (2018) Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome: A review. Phytotherapy Research, 32 (10). pp. 1933-1949.

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Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome A review.pdf

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Abstract

Metabolic syndrome describes a complex metabolic risk factors including obesity, hypertension, dyslipidemia, and diabetes. This syndrome is diagnosed by medical conditions such as weight gain, high blood pressure, high blood glucose, and disturbance in lipid profile. Metabolic syndrome has become as an important and increasing global health problem, so finding potentially novel solutions with less adverse effects is favorable for health problems. Herbal therapy plays an important role for treatment of different diseases. Silybum marianum is a plant that is used for centuries as a herbal treatment in liver and biliary tract diseases. Silymarin is the main component of S. marianum and derived from fruits and seeds of S. marianum (milk thistle). S. marianum has been found to exhibit antioxidant, lipid-lowering, antihypertensive, antidiabetic, antiatherosclerotic, anti-obesity, and hepatoprotective effects. Therefore, the aim of this review is to summarize different animal and human studies regarding the effect of S. marianum in metabolic syndrome and to identify the underlying mechanisms of action. © 2018 John Wiley & Sons, Ltd.

Item Type: Article
Additional Information: Cited By :11 Export Date: 16 February 2020 CODEN: PHYRE Correspondence Address: Hosseinzadeh, H.; Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical SciencesIran; email: hosseinzadehh@mums.ac.ir
Uncontrolled Keywords: diabetes dyslipidemia hypertension metabolic syndrome milk thistle obesity silibyn Silybum marianum silymarin herbaceous agent lipid plant extract antioxidant activity blood pressure diabetes mellitus drug effect drug mechanism heart protection human liver protection metabolic syndrome X nonhuman Review animal chemistry fruit plant seed randomized controlled trial (topic) Animals Humans Plant Extracts Randomized Controlled Trials as Topic Seeds
Subjects: WK Endocrine System
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 04 May 2020 02:42
Last Modified: 04 May 2020 02:42
URI: http://eprints.mums.ac.ir/id/eprint/17555

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