First trimesters Pregnancy-Associated Plasma Protein-A levels value to Predict Gestational diabetes Mellitus: A systematic review and meta-analysis of the literature

Talasaz, Z. H. and Sadeghi, R. and Askari, F. and Dadgar, S. and Vatanchi, A. (2018) First trimesters Pregnancy-Associated Plasma Protein-A levels value to Predict Gestational diabetes Mellitus: A systematic review and meta-analysis of the literature. Taiwanese Journal of Obstetrics and Gynecology, 57 (2). pp. 181-189.

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Abstract

Detecting pregnant women at risk of diabetes in first months can help them by early intervention for delaying or preventing onset of GDM. In this study, we aimed to assess the Predictive value of first trimester Pregnancy related plasma protein-A (PAPP-A) levels for detecting Gestational diabetes Mellitus (GDM). This systematic review and meta-analysis was conducted through probing in databases. PubMed, Scopus, Medline and Google scholar citations were searched to find the published papers from 1974 to 2017. Studies were considered eligible if they were cohorts, case–control studies, reported GDM result, not other types, conducted on singleton pregnancy, measured Serum pregnancy associated plasma protein A in the first trimester and evaluated the relation of first trimester pregnancy associated plasma protein–A and GDM. Two reviewers independently assessed the quality with Newcastle–Ottawa and extracted data in the Pre-defined checklist. Analysis of the data was carried out by “Comprehensive Meta-analysis Version 2 (CAM)” and Metadisc software. 17 articles have our inclusion criteria and were considered in our systematic review, 5 studies included in Meta-analysis. Meta-analysis of these articles showed that the predictive value of PAPP-A for GDM has 55 sensitivity (53–58), 90 (89–90) specificity, LR + 2.48 (0.83–7.36) and LR − 0.70 (0.45–1.09) with 95 confidence intervals. In our study PAPP-A has low predictive accuracy overall, but it may be useful when combined with other tests, and this is an active part for future research. One limitation of our study is significant heterogeneity because of different adjusted variables and varied diagnostic criteria. © 2018

Item Type: Article
Additional Information: Cited By :4 Export Date: 16 February 2020 Correspondence Address: Dadgar, S.; Faculty of Medicine, Obstetrics & Gynecology Department, Mashhad University of Medical SciencesIran; email: DadgarS@mums.ac.ir
Uncontrolled Keywords: First trimesters Gestational diabetes Mellitus Pregnancy-Associated Plasma Protein-A Systematic review pregnancy associated plasma protein A biological marker diagnostic accuracy diagnostic test accuracy study first trimester pregnancy human Medline meta analysis (topic) predictive value pregnancy diabetes mellitus pregnant woman protein blood level Review Scopus sensitivity and specificity blood case control study cohort analysis female meta analysis pregnancy Biomarkers Case-Control Studies Cohort Studies Diabetes, Gestational Humans Pregnancy Trimester, First
Subjects: WK Endocrine System
WQ Obstetrics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 04 May 2020 02:49
Last Modified: 04 May 2020 02:49
URI: http://eprints.mums.ac.ir/id/eprint/17556

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