Oxidative stress and kidney injury in trans-radial catheterization

Tsarouhas, K. and Tsitsimpikou, C. and Papantoni, X. and Lazaridou, D. and Koutouzis, M. and Mazzaris, S. and Rezaee, R. and Mamoulakis, C. and Georgoulias, P. and Nepka, C. and Rentoukas, E. and Kyriakides, Z. and Tsatsakis, A. and Spandidos, D. A. and Kouretas, D. (2018) Oxidative stress and kidney injury in trans-radial catheterization. Biomedical Reports, 8 (5). pp. 417-425.

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Abstract

Oxidative stress is linked to coronary artery disease and is a major mechanism in contrast-induced nephropathy. Trans-radial approach in coronary angiography (CA) with minimized peri-procedural bleeding is expected to reduce acute kidney injury incidence. In the present study, oxidative stress patterns observed in radial CA and their associations with early manifestations of kidney injury are described. A total of 20 stable coronary disease patients submitted to CA and 17 sex-matched patients undergoing computed tomography for myoskeletal reasons were enrolled. Reduced glutathione, catalase, thiobarbituric acid reactive species (TBARS) levels and total anti-oxidant status were measured at various time points postangiography. In ischemic patients baseline TBARS levels were 2-fold lower compared to controls, while carbonyls levels were 35 higher. Glutathione was almost 4-fold lower than the control group. Glutathione and lipid peroxidation in ischemic patients gradually increased after contrast medium administration and reached 180 (P<0.001) and 20 (P=0.021) after 4-6 h, respectively. Four patients presented early evidence of contrast-induced nephropathy postangiography, while no control patient developed acute kidney injury. In the multiple logistic regression analysis, only the creatinine levels at baseline influenced the frequency of early contrast-induced nephropathy development (β =0.36, 95 CI: 0.285-0.438, P=0.01). Glutathione low levels were dominant in the baseline values of ischemic patients who developed contrast-induced nephropathy. Glutathione levels rapidly increased while protein oxidation decreased at the expense of lipid peroxidation. In conclusion, early oxidative stress changes occur in trans-radial CA patients with a mild profile, sufficient to mobilize patient antioxidant defenses. © 2018, Spandidos Publications. All rights reserved.

Item Type: Article
Additional Information: Cited By :8 Export Date: 16 February 2020 Correspondence Address: Tsarouhas, K.; Department of Cardiology, University Hospital of Larissa, Terma Mezourlo, Greece; email: ktsarouhas14@yahoo.gr
Uncontrolled Keywords: Contrast-induced nephropathy Oxidative stress Trans-radial catheterization alanine aminotransferase aspartate aminotransferase carbonyl derivative catalase cholesterol creatine kinase creatinine gamma glutamyltransferase glutathione hemoglobin high density lipoprotein cholesterol iopromide lactate dehydrogenase low density lipoprotein cholesterol potassium sodium thiobarbituric acid reactive substance triacylglycerol urea uric acid adult aged angiography Article catheterization clinical article computer assisted tomography contrast induced nephropathy coronary artery disease DPPH radical scavenging assay enzyme assay female hematocrit human hydration immunoradiometric assay insulin resistance kidney function kidney injury lipid peroxidation male middle aged neutrophil lymphocyte ratio percutaneous coronary intervention platelet lymphocyte ratio very elderly
Subjects: WJ Urogenital System
WN Radiology . Diagnostic Imaging
QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 28 Apr 2020 03:52
Last Modified: 28 Apr 2020 03:52
URI: http://eprints.mums.ac.ir/id/eprint/17564

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