Is transvaginal core needle biopsy a safe method in diagnosis of ovarian cancer?

Yousefi, Z. and Frazestanian, M. and Davachi, B. and Saeed, S. and Azad, A. and Khorasani, S. T. (2018) Is transvaginal core needle biopsy a safe method in diagnosis of ovarian cancer? International Journal of Cancer Management, 11 (2).

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Background: The optimal management of highly invasive ovarian cancer has changed from adjuvant chemotherapy after surgery to neoadjuvant chemotherapy followed by interval debulking surgery. Generally, tissue specimen for definitive diagnosis of ovarian malignancy is necessary. However, abdominal wall metastasis is a complication, known as transabdominal ascites aspiration or percutaneous core needle biopsy. When neoadjuvant chemotherapy is indicated, transvaginal core needle biopsy under sonographic guidance provided enough tissue specimens. In addition, resection of most of upper vaginal wall during surgery prevents needle site metastasis. The aim of this study is to evaluate transvaginal core needle biopsy as a safe method for diagnosis of ovarian cancer. Methods: This clinical trial study was performed on patients who were candidate for neoadjuvant chemotherapy and were referred to gynecology oncology department of Ghaem Hospital, Mashhad University of Medical Sciences during 2014 to 2015. Results: Twelve women with a presumptive diagnosis of stage III c or IV ovarian cancer were selected. Adequate sample was obtained by transvaginal core needle biopsy, and cancer diagnosis was confirmed in all cases. This procedure resulted in optimal debulking surgery in 2/3 of cases. Conclusions: Transvaginal core needle biopsy is a safe diagnostic method of ovarian cancer. © 2017, Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 Correspondence Address: Saeed, S.; Department of Obstetrics and Gynecology, Ghaem Hospital, School of Medicine, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: Diagnosis Ovarian cancer Transvaginal core needle biopsy CA 125 antigen abdominal discomfort abdominal wall defect adult aged Article cancer diagnosis clinical article cytoreductive surgery demography female hemodynamics histology human human tissue metastasis middle aged needle biopsy observational study oncology ovary carcinoma pain pathology rectouterine pouch transvaginal echography ultrasound vagina disease very elderly x-ray computed tomography young adult
Subjects: WP Gynecology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 03 Mar 2020 10:37
Last Modified: 03 Mar 2020 10:37

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