Teucrium polium L. improves blood glucose and lipids and ameliorates oxidative stress in heart and aorta of diabetic rats

Zabihi, N. A. and Mousavi, S. M. and Mahmoudabady, M. and Soukhtanloo, M. and Sohrabi, F. and Niazmand, S. (2018) Teucrium polium L. improves blood glucose and lipids and ameliorates oxidative stress in heart and aorta of diabetic rats. International Journal of Preventive Medicine, 9 (1).

[img] Text
Teucrium polium L. improves blood glucose and lipids and ameliorates oxidative stress in heart and aorta of diabetic rats.pdf

Download (1MB)

Abstract

Background: Diabetes mellitus (DM) is a prime risk factor for cardiovascular disease. The convincing experimental and clinical evidence indicated that the onset of DM is closely associated with oxidative stress and that the generation of reactive oxygen species increases in both the types of diabetes. The aim of the present study was to evaluate the effect of Teucrium polium (TP) hydroalcoholic extract on the blood glucose, cholesterol, triglyceride, and oxidative stress markers of the heart and aorta in streptozotocin (STZ)-induced diabetic rats. Methods: The male Wistar rats assigned into six groups (n = 8 in each group): Control, diabetic, and diabetic rats treated with TP extract (100, 200, and 400 mg/kg) or met and metformin (300 mg/kg) formin (300 mg/kg) group, by daily gavage for 6 weeks. Diabetes was induced by injection of STZ (60 mg/kg, i.p). Serum lipids and glucose, malondialdehyde (MDA) level, total thiol level, and also the activities of Cu, Zn-superoxide dismutase (SOD) in the cardiac and aortic tissues were assessed. Results: TP extract reduced serum glucose, triglyceride and cholesterol. The MDA levels were reduced significantly in all TP-treated groups and metformin. Total thiol levels were improved in the heart and aorta of TP extract-treated groups and metformin compared to the diabetic rats. The activity of SOD in the cardiac and aortic tissues of TP extract- and metformin-treated groups was higher than diabetic group. Conclusions: The results showed that chronic administration of TP in STZ-induced diabetic rats could decrease blood glucose, cholesterol, and triglyceride and also attenuate the oxidative stress in the aortic and cardiac tissues. © 2018 Journal of Research in Medical Sciences | Published by Wolters Kluwer - Medknow.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Niazmand, S.; Department of Physiology, Faculty of Medicine, Mashhad University of Medical SciencesIran; email: niazmands@mums.ac.ir
Uncontrolled Keywords: Aorta diabetes mellitus heart oxidative stress Teucrium polium antidiabetic agent antioxidant cholesterol copper zinc superoxide dismutase glucose malonaldehyde metformin reactive oxygen metabolite streptozocin Teucrium polium extract thiol triacylglycerol animal experiment animal model antidiabetic activity antioxidant activity aortic tissue Article controlled study drug isolation drug synthesis germander glucose blood level heart tissue lipid blood level male nonhuman rat streptozotocin-induced diabetes mellitus treatment duration
Subjects: WG Cardiovascular System
WK Endocrine System
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 03 Mar 2020 10:36
Last Modified: 03 Mar 2020 10:36
URI: http://eprints.mums.ac.ir/id/eprint/17581

Actions (login required)

View Item View Item