Gankyrin: a novel promising therapeutic target for hepatocellular carcinoma

Zamani, P. and Matbou Riahi, M. and Momtazi-Borojeni, A. A. and Jamialahmadi, K. (2018) Gankyrin: a novel promising therapeutic target for hepatocellular carcinoma. Artificial Cells, Nanomedicine and Biotechnology, 46 (7). pp. 1301-1313.

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Abstract

Hepatocellular carcinoma (HCC) is known as fifth common malignancies and third common cause of cancer-related death worldwide. The identification of various mechanisms which are involved in hepatocarcinogenesis contributes in finding a variety of cellular and molecular targets for HCC diagnosis, prevention and therapy. Among various identified targets in HCC pathogenesis, Gankyrin is a crucial oncoprotein that is up-regulated in HCC and plays a pivotal role in the initiation and progression of the HCC. Oncogenic role of Gankyrin has been found to stem from inhibition of two ubiquitous tumour suppressor proteins, retinoblastoma protein (pRb) and P53, and also modulation of several vital cellular signalling pathways including Wnt/β-Catenin, NF-κB, STAT3/Akt, IL-1β/IRAK-1 and RhoA/ROCK. As a result, Gankyrin can be considered as a potential candidate for diagnosis and treatment of HCC. In this review, we summarized the physiological function and the significant role of Gankyrin as an important therapeutic target in HCC. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: Cited By :9 Export Date: 16 February 2020 Correspondence Address: Jamialahmadi, K.; Department of Medical Biotechnology, Faculty of Medicine, Pardis Campus, Azadi Square, Iran; email: jamialahmadikh@mums.ac.ir
Uncontrolled Keywords: Gankyrin hepatocellular carcinoma oncoprotein signalling pathway Proteins Hepatocarcinogenesis Oncoproteins Physiological functions Retinoblastoma proteins (pRb) Signalling pathways Tumour suppressor protein Diagnosis beta catenin immunoglobulin enhancer binding protein interleukin 1 receptor associated kinase 1 interleukin 1beta messenger RNA microRNA panobinostat protein gankyrin protein kinase protein kinase B protein p53 protein rock retinoblastoma protein RhoA guanine nucleotide binding protein small interfering RNA STAT3 protein stress activated protein kinase tumor marker unclassified drug Wnt protein drug targeting epigenetics human liver cell carcinoma malignant neoplasm nonhuman protein function protein protein interaction protein structure Review signal transduction animal chemistry enzymology genetics liver tumor metabolism molecularly targeted therapy pathology procedures Animals Carcinoma, Hepatocellular Humans Liver Neoplasms Molecular Targeted Therapy Proto-Oncogene Proteins
Subjects: QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 03 Mar 2020 09:30
Last Modified: 03 Mar 2020 09:30
URI: http://eprints.mums.ac.ir/id/eprint/17585

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