Hemodynamic responses to etomidate versus ketamine-thiopental sodium combination for anesthetic induction in coronary artery bypass graft surgery patients with low ejection fraction: A double-blind, Randomized, Clinical trial

Habibi, M. R. and Baradari, A. G. and Soleimani, A. and Zeydi, A. E. and Nia, H. S. and Onagh, N. (2014) Hemodynamic responses to etomidate versus ketamine-thiopental sodium combination for anesthetic induction in coronary artery bypass graft surgery patients with low ejection fraction: A double-blind, Randomized, Clinical trial. Journal of Clinical and Diagnostic Research, 8 (10). GC01-GC05.

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Abstract

Background: During induction of anesthesia and intubation, hemodynamic changes are very important; especially in patients with coronary artery disease (CAD) and left ventricular dysfunction. A little information is available on the hemodynamic effects of a combination of ketamine-thiopental for induction of anesthesia in patients undergoing coronary artery bypass graft (CABG) surgery, with impaired ventricular function. Aim: The aim of this study was to compare the hemodynamic responses to etomidate versus ketamine-thiopental sodium combination for anesthetic induction in CABG surgery patients with low ejection fraction (EF<45). Materials and Methods: In a double blind randomized clinical trial, a total of 100 patients, scheduled for elective CABG surgery were randomly assigned into two groups. These patients received either etomidate or ketamine-thiopental sodium combination at induction of anesthesia. Hemodynamics variable were measured and recorded at baseline, immediately before and after laryngoscopy and intubation, one, two and three minutes after intubation. Also, muscle twitching incidence among patients in two groups was evaluated. Results: No significant differences between the two groups regarding the changes of hemodynamic variables including systolic and diastolic arterial blood pressure, mean arterial pressure and heart rate, were notice (p>0.05). Muscle twitching was not observed in the two groups. Conclusion: Hemodynamic stability after administration of ketamine-thiopental sodium combination for induction of anesthesia in patients undergoing CABG surgery, with impaired ventricular function, supports the clinical impression that this combination is safe in CABG surgery patients with low EF. © 2014, Journal of Clinical and Diagnostic Research. All Rights Reserved.

Item Type: Article
Additional Information: Cited By :8 Export Date: 16 February 2020 Correspondence Address: Habibi, M.R.; Department of Anesthesiology, Mazandaran University of Medical Sciences, Hazrat Fatima HospitalIran
Uncontrolled Keywords: Anesthesia CABG Etomidate Hemodynamic Thiopental sodium ephedrine fentanyl ketamine midazolam placebo suxamethonium thiopental adult aged anesthesia induction arterial pressure Article controlled study coronary artery bypass graft diastolic blood pressure double blind procedure electrocardiography female heart ejection fraction heart rate hemodynamics human informed consent intubation laryngoscopy major clinical study male muscle twitch premedication pulse oximeter randomized controlled trial systolic blood pressure
Subjects: WO Surgery
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib6 lib6
Date Deposited: 21 Oct 2020 10:13
Last Modified: 21 Oct 2020 10:13
URI: http://eprints.mums.ac.ir/id/eprint/17767

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