Serum inflammatory cytokines and depression in coronary artery disease

Tajfard, M. and Latiff, L. A. and Reza Rahimi, H. and Mouhebati, M. and Esmaeily, H. and Taghipour, A. and Mahdipour, E. and Davari, H. and Saghiri, Z. and Hanachi, P. and Ghayour Mobarhan, M. and Ferns, G. A. and Azizian, M. (2014) Serum inflammatory cytokines and depression in coronary artery disease. Iranian Red Crescent Medical Journal, 16 (7).

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Background: Severe depression may be accompanied by immune dysregulation and is also associated with increased risk of coronary artery disease (CAD). Objectives: We investigated serum levels of 10 cytokines and their relationship with depression in patients with cardiovascular diseases as well as healthy subjects in northeast of Iran. Patients and Methods: The study was carried out on 462 subjects (120 healthy subjects and 342 candidates undergoing angiography). The healthy subjects were referred for routine annual checkups or pre-employment examinations; they did not have clinically evident CAD. A questionnaire was used to obtain demographic data and the Beck depression inventory (BDI) was applied to assess depression. The Evidence Investigator® platform was used for cytokines assays for IL-1a, IL-1ß, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-a, MCP-1 and IFN-?, using sandwich chemiluminescent method. The statistical analysis was performed using SPSS version 11.5. Results: The mean age was 53.3 ± 11.5, 54.8 ± 11.3, and 59.5 ± 11.3 in healthy, angiography (-), and angiography (+) subjects, respectively (P < 0.05). There were significant differences in serum levels of IL-4, IL-6, IL-10, and MCP-1 cytokines, comparing subjects with CAD and healthy persons (P < 0.05). When all subjects were divided to with and without depression regardless of their cardiovascular status, there was a significant difference in serum levels of IL-8 and IL-6 between the groups (P < 0.05). When the subgroup with features of CAD was selected and divided to those with and without depression, there was also a significant difference in serum levels of IL-8 and TNF-a (P < 0.05). Conclusions: The positive interaction between depression and CAD was probably mediated by inflammatory mechanisms. © 2014, Iranian Red Crescent Medical Journal.

Item Type: Article
Additional Information: Cited By :11 Export Date: 16 February 2020 Correspondence Address: Mobarhan, M. G.; Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; email:
Uncontrolled Keywords: Coronary artery disease Cytokines Depression Interleukin-8 Tumor necrosis factor
Subjects: WG Cardiovascular System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib6 lib6
Date Deposited: 04 Nov 2020 14:04
Last Modified: 04 Nov 2020 14:04

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