Efficacy of insulin targeted gene therapy for type 1 diabetes mellitus: A systematic review and meta-analysis of rodent studies

Rahimi Ghiasi, Moosa and Mohammadi, Hamed and Symonds, Michael and Tabei, Seyed Mohammad Bagher and Salehi, Ahmad Reza and Jafarpour, Sima and Norouzi Barough, Leila and Rahimi, Elnaz and Amirkhani, Zohreh and Miraghajani, Maryam and Salehi, Rasoul (2020) Efficacy of insulin targeted gene therapy for type 1 diabetes mellitus: A systematic review and meta-analysis of rodent studies. Iranian Journal of Basic Medical Sciences, 23 (4). pp. 406-415.

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Objective(s): Diabetes mellitus (DM) is a major worldwide public health challenge, for which gene therapy offers a potential therapeutic approach. To date, no systematic review or meta-analysis has been published in this area, so we examined all relevant published studies on rodents to elucidate the overall effects of gene therapy on bodyweight, intraperitoneal glucose tolerance test (IPGTT), fasting blood glucose, and insulin in animals with type 1 DM. Materials and Methods: The Cochrane Library, PubMed, Embase, ISI Web of Science, SCOPUS, and Google Scholar were systematically searched for potentially relevant studies. Mean±standard deviation (SD) was pooled using a random-effects model.Results: After the primary search, out of 528 studies identified, 16 studies were in concordance with predefined criteria and selected for the final assessment. Of these, 12 studies used viral manipulation, and 4 employed non-viral vectors for gene delivery. The meta-analysis showed gene therapy with a viral vector decreased mean IPGTT (-12.69 mmol/l, P<0.001), fasting blood glucose (-13.51 mmol/l, P<0.001), insulin (398.28 pmol/l, P<0.001), and bodyweight (24.22 g, P<0.001), whereas non-viral vectors reduced fasting glucose (-29.95 mmol/l, P<0.001) and elevated insulin (114.92 pmol/l, P<0.001).Conclusion: Gene therapy has favorable effects on alleviating type 1 DM related factors in diabetic rodents.

Item Type: Article
Uncontrolled Keywords: Gene Therapy,Insulin,Meta-analysis,Non-viral vector,Type 1 Diabetes Mellitus,Viral vector
Subjects: QU Biochemistry
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 24 Jun 2020 05:13
Last Modified: 24 Jun 2020 05:13
URI: http://eprints.mums.ac.ir/id/eprint/18033

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