High proviral load of human T cell lymphotropic virus type-1 facilitates coronary artery diseases

Mozayeni, Farnaz and Rezaee, Seyed Abdolrahim and Jabbari Azad, Farahnaz and Shabestari, Mahmoud and Faridhosseini, Reza and Rafatpanah, Houshang and Yousefzadeh, Hadis and Garivani, Yousef Ali and Jarahi, Lida and Valizadeh, Narges and Sabet, Faezah and Moshirahmadi, Sharare and Mohammadi, Fatemeh Sadat and Shabestari, Mohammad (2020) High proviral load of human T cell lymphotropic virus type-1 facilitates coronary artery diseases. Iranian Journal of Basic Medical Sciences, 23 (4). pp. 500-506.

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Official URL: http://ijbms.mums.ac.ir/article_14627.html


Objective(s): Coronary artery disease (CAD) is known as a life threatening disease, worldwide. In this study the role of HTLV-1 infection was evaluated on cardiac involvement in an endemic region of northeastern Iran.Materials and Methods: Serologic and molecular tests for HTLV-1 infection were carried out in subjects who had coronary angiography. A real-time PCR, TaqMan method, to quantify HTLV-1 proviral load (PVL), and routine hematological and biochemical tests were performed for study subjects. Results: Twenty nine patients were HTLV-1ࠀ and 13 cases were HTLV-1ࠀ. Although, there were no significant differences for risk factors like FBS, HDL, triglyceride, systolic and diastolic blood pressure (Cbp, Dbp), waist circumference (WC), hip circumference (WL), cholesterol (P=0.003), and LDL (P=0.007) levels, and monocyte count (P=0.05) had meaningful differences. The mean HTLV-1 PVL in HTLV-1ࠀ subjects was 992.62±120 which was higher compared with HTLV-1ࠀ group (406.54±302 copies/104 PBMCs). Moreover, HTLV-1 PVL in males (833±108) was lower compared with females (1218±141 copies/104 PBMCs) (P=0.05). Patients with HTLV-1-PVL of more than 500 copies/104 had more diffused atherosclerosis plaque than patients with less than 500 (OR=6.87, 95 CI=1.34-35.05; P=0.016). Furthermore, patients with diffused coronary atherosclerosis had significantly higher levels of HTLV-1 PVL than patients with middle, proximal, and normal location of coronary sclerotic lesions (P<0.05). Conclusion: Taken together, in endemic area, HTLV-1 infection, more likely is a facilitating factor for heart complications and the high HTLV-1 PVL might affect CAD manifestations.

Item Type: Article
Uncontrolled Keywords: Cardiac involvement,Coronary artery disease HTLV-1,HTLV-1 Proviral load,Real-time PCR
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 24 Jun 2020 05:02
Last Modified: 24 Jun 2020 05:02
URI: http://eprints.mums.ac.ir/id/eprint/18043

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