The effect of lycopene in egg shell membrane guidance channel on sciatic nerve regeneration in rats

Farjah, Gholam Hossein and Mohammadzadeh, Samad and Zirak Javanmard, Masoumeh (2020) The effect of lycopene in egg shell membrane guidance channel on sciatic nerve regeneration in rats. Iranian Journal of Basic Medical Sciences, 23 (4). pp. 527-533.

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Abstract

Objective(s): Peripheral nerves are commonly damaged. Although the nerve autograft still subsists the gold standard in surgery of nerve injury gaps, it has severe detriment. The egg shell membrane (ESM) is a natural material, which has a great potential in practice. The aim of this survey was to appraise the effect of lycopene and the ESM nerve guidance channel on sciatic nerve regeneration.Materials and Methods: In this study, 32 male rats were randomized into four groups: sham surgery, autograft, ESM+ dimethyl sulfoxide (DMSO), and ESM霧⢥. One centimeter of sciatic nerve was removed, and the gap was grafted by ESM channel or autograft. The sciatic function index (SFI) was evaluated at days 7, 21, 30, 49, 60 and 90 after surgery. Nerve regeneration and gastroknemius muscle fibers were evaluated at days 30 and 90 after surgery by withdrawal reflex latency (WRL), histology and immunohistology assessments.Results: At 49, 60 and 90 days after surgery, the mean SFI in ESM霧⢥ group was significantly greater than ESMೄ group (P<0.05). On day 90, the mean muscle fiber diameters and the mean number of myelinated axons in ESM霧⢥ and autograft groups were significantly greater than ESMೄ group (P<0.05). In addition, the mean WRL was significantly lower in ESM霧⢥ group than in the ESMೄ group 90 days after surgery (P<0.05).Conclusion: The results of this study show that the affirmative effects of ESM霧⢥ may be beneficial for treating peripheral nerve damages.

Item Type: Article
Uncontrolled Keywords: Egg shell membrane,Lycopene,Nerve guidance channel,Nerve regeneration,Rat,Sciatic nerve
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 24 Jun 2020 05:12
Last Modified: 24 Jun 2020 05:12
URI: http://eprints.mums.ac.ir/id/eprint/18046

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