Preparation and <i>in vivo</i> evaluation of nanoliposomes containing vancomycin after intravitreal injection in albino rabbits

Abrishami, Majid and Motamed Shariati, Mehrdad and Malaekeh-Nikouei, Bizhan and Sadat Tajani, Amineh and Mahmoudi, Asma and Abrishami, Mojtaba and Khameneh, Bahman (2020) Preparation and <i>in vivo</i> evaluation of nanoliposomes containing vancomycin after intravitreal injection in albino rabbits. Iranian Journal of Basic Medical Sciences, 23 (4). pp. 551-555.

[img] Text
IJBMS_Volume 23_Issue 4_Pages 551-555.pdf

Download (475kB)
Official URL: http://ijbms.mums.ac.ir/article_14967.html

Abstract

Objective(s): The in vivo efficacy of nanoliposomal formulation of vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) assessed.Materials and Methods: Nanoliposomal formulations were prepared and characterized. The in vivo study was carried out on rabbits which received liquid culture medium containing MRSA under anesthesia. After 48 hr, the eyes treated with the liposomal and free form of vancomycin. The rabbits were euthanized at predesignate intervals at 12, 24, 48, 96, 144 hr intervals injection. The antibacterial activity of different vancomycin formulations was assayed by the time killing method. Results: The zeta potential, mean sizes and encapsulation efficacy of liposomal vancomycin were 29.7 mV, 381.93±30.13 nm and 47, respectively. The results of time�killing studies indicated that the liposomal formula was more effective than the free form of vancomycin.Conclusion: The results of this study revealed that liposomal vancomycin formulation is a powerful nano-antibacterial agent to combat infectious endophthalmitis.

Item Type: Article
Uncontrolled Keywords: Nanopliposomes,Vancomycin,Endophthalmitis,MRSA,Drug Delivery
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 24 Jun 2020 04:45
Last Modified: 24 Jun 2020 04:45
URI: http://eprints.mums.ac.ir/id/eprint/18049

Actions (login required)

View Item View Item