Protective effect of interleukin-36 receptor antagonist on liver injury induced by concanavalin A in mice

Peng, Xiao and Pan, Xiuhe and Tan, Jun and Li, Yan and Li, Mingcai (2020) Protective effect of interleukin-36 receptor antagonist on liver injury induced by concanavalin A in mice. Iranian Journal of Basic Medical Sciences, 23 (5). pp. 623-628.

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Abstract

Objective(s): Interleukin-36 receptor antagonist (IL-36Ra) is a new member of the IL-1 family that exhibits anti-inflammatory activity in a variety of inflammatory and immune diseases. Our purpose was to determine the effect of IL-36Ra on liver injury in a mouse hepatitis model induced by concanavalin A (ConA). Materials and Methods: Mice were treated with IL-36Ra DNA or pcDNA3.1 control plasmid using a hydrodynamic gene delivery approach. Results: Our data reveal that treatment with IL-36Ra decreased liver inflammation and serum level of aminotransferases. Furthermore, IL-36Ra reduced ConA-induced pro-inflammatory cytokines (interferon-γ, tumor necrosis factor-α, and IL-17A) production when compared to control plasmid. Conclusion: Our results demonstrated that IL-36Ra is a critical protector against ConA-induced liver injury.

Item Type: Article
Uncontrolled Keywords: Concanavalin A (ConA),Hydrodynamic-based gene delivery,IL-36Ra,Inflammation,Liver injury,Plasmid
Subjects: QU Biochemistry
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 24 Jun 2020 04:15
Last Modified: 24 Jun 2020 04:15
URI: http://eprints.mums.ac.ir/id/eprint/18058

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