Effectiveness of Fresh Frozen Plasma in Management of Acute Organophosphate Intoxicated Patients: An Updated Systematic Review and Meta-Analysis

Nafea, Ola and Aziz, Mohamed and Saptan, Fatma and Abdalla, Ahmed and Ibrahim, Hend (2019) Effectiveness of Fresh Frozen Plasma in Management of Acute Organophosphate Intoxicated Patients: An Updated Systematic Review and Meta-Analysis. Asia Pacific Journal of Medical Toxicology, 8 (3). pp. 95-100.

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Abstract

Background:Organophosphate (OP) poisoning is still a major health concern in both developed and developing countries. The standard treatment approaches of (OP) poisoning are not always available as well so they may show a limited success rate. Fresh frozen plasma (FFP) is one of Bio-scavengers that have been suggested as a useful therapy through elimination of free organophosphates. Therefore, this systematic review and meta-analysis was conducted to update the present evidence about the efficacy of FFP in management of acute OP-intoxicated patients. Method:A computer literature search of PubMed and Scopus was conducted to identify the relevant randomized controlled trials (RCTs). In addition, a manual search of reference lists of the retrieved articles was conducted. Relevant outcomes were pooled as mean difference (MD) risk ratio (RR) by RevMan version 5.3 for Windows. Results:Pooled data from 3 RCTs (169 patients) showed that adding FFP to conventional therapy to acutely OP intoxicated patients did not improve clinical outcomes regarding total atropine (MD = 35.05, 95 CI = -41.14 to 111.24, P-value = 0.37) and pralidoxime dosages (MD = -0.41, 95% CI = -2.34 to 1.51, P-value = 0.67), length of hospital stay (MD = -2.08, 95% CI = -4.51 to 0.35, P-value = 0.09) and mortality (RR = 0.42, 95% CI = 0.14 to 1.27, P-value = 0.12). Conclusion: Fresh frozen plasma did not provide any additional benefit in acutely-OP intoxicated patients compared to the conventional therapy. The limited number and sizes of the included trials are the most probable cause of such effects.

Item Type: Article
Uncontrolled Keywords: Atropine,Fresh Frozen Plasma,Meta-analysis,Organophosphate,Pralidoxime
Subjects: QV pharmacology
Divisions: Journals > Asia Pacific J Toxicology
Depositing User: apjmt apjmt
Date Deposited: 08 Apr 2020 05:39
Last Modified: 08 Apr 2020 05:39
URI: http://eprints.mums.ac.ir/id/eprint/18178

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