Determination of cut point in the age of colorectal cancer diagnosis using a survival cure model

Abdollahi, M. and Kasiri, N. and Pourhoseingholi, M. A. and Baghestani, A. R. and Esmaily, H. (2019) Determination of cut point in the age of colorectal cancer diagnosis using a survival cure model. Asian Pacific Journal of Cancer Prevention, 20 (9). pp. 2819-2823.

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Abstract

Background and Objectives: Colorectal Cancer (CRC) is the fourth cancer-related cause of death worldwide. CRC is a multi-stage cancer, which is curable during the early stages of the disease. Therefore, determining the time of cut-point existence could improve treatment planning and help directly allocate resources. This study aims to determine the cut point in the age of CRC diagnosis. Methods: This study, covering the course 1985 to 2012, consisted of 345 colorectal cancer patients registered in Taleghani Hospital, Tehran, Iran and followed up to 2013. The cut-point in the age of CRC diagnosis was obtained using a mixture cure model. The data were analyzed using SPSS and R, V. 20 and 2.15.0, respectively. Results: The results showed that the cut point in the age of CRC diagnosis was 50 years. Based on our estimation, 65 of the patients diagnosed with CRC at or younger than 50 were cured, while 31 of them diagnosed older than 50 were cured, and the younger group had a better survival over the older group. Conclusion: Since access to a cut-point and analysis of created prognostic groups are important in screening and treatment planning, our results suggested that it is better to estimate the cut-point in the age of curable cancers in early stages via survival cure models, and the cure rate would increase by CRC timely screening. © 2019 Asian Pacific Organization for Cancer Prevention.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Abdollahi, M.; Department of Public Health, School of Health, Torbat Heydariyeh University of Medical SciencesIran; email: Abdollahim2@thums.ac.ir
Uncontrolled Keywords: Colorectal Cancer Cut point Survival analysis Survival cure model
Subjects: QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 04:56
Last Modified: 21 Jun 2020 04:56
URI: http://eprints.mums.ac.ir/id/eprint/18222

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