An investigation into the effects of magnesium sulfate on the complications of succinylcholine administration in nulliparous women undergoing elective cesarean section: A double-blind clinical trial

Aghamohamadi, D. and Gol, M. K. (2019) An investigation into the effects of magnesium sulfate on the complications of succinylcholine administration in nulliparous women undergoing elective cesarean section: A double-blind clinical trial. International Journal of Women's Health and Reproduction Sciences, 7 (4). pp. 520-525.

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Abstract

Objectives: Controlling the complications of anesthetics (e.g., succinylcholine) seems necessary since they are greater for nulliparous women who undergo elective cesarean section (C-section). The present study aimed to investigate the effects of magnesium sulfate on the complications of succinylcholine administration in nulliparous women undergoing elective C-section. Materials and Methods: This double-blind clinical trial was conducted on 60 nulliparous women during 2012-2013. The women were randomly assigned to A and B groups. Before inducing the rapid anesthesia with succinylcholine, patients in the intervention group received 30 mg/kg of magnesium sulfate within 10 minutes and then the hemodynamic status and the side effects of succinylcholine were recorded in a special form. Statistical tests were performed using repeated-measures ANOVA, chi-square test, and one-way ANOVA tests and the level of significance was determined to be P < 0.05. Results: There was no significant difference between the two groups in terms of demographic data (P > 0.059). However, the results indicated that there was a significant difference between the 2 groups regarding the myoglobin level (P = 0.010). Contrarily, the results showed that most patients in the intervention (n=23) and control (n=15) groups experienced no or mild and severe fasciculation, respectively (P < 0.001). Conclusions: In general, magnesium sulfate can greatly control and reduce the complications of succinylcholine administration, including fasciculation. © 2019 The Author (s).

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Gol, M.K.; Responsible for the Nursing Research Committee of Imam Reza Hospital, Tabriz University of Medical SciencesIran; email: Mkhanbabayi@yahoo.com
Uncontrolled Keywords: Fasciculation Magnesium sulfate Succinylcholine magnesium myoglobin potassium suxamethonium adult Aldrete score anesthesia induction anesthetic recovery Article cesarean section clinical article controlled study diastolic blood pressure double blind procedure endotracheal intubation female heart rate hemodynamics human laryngoscopy myalgia myoglobinuria nullipara numeric rating scale oxygen saturation pain severity postoperative pain randomized controlled trial systolic blood pressure treatment duration
Subjects: WQ Obstetrics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 04:58
Last Modified: 21 Jun 2020 04:58
URI: http://eprints.mums.ac.ir/id/eprint/18230

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