Transfusion-transmitted malaria: A systematic review and meta-analysis

Ahmadpour, E. and Foroutan-Rad, M. and Majidiani, H. and Moghaddam, S. M. and Hatam-Nahavandi, K. and Hosseini, S. A. and Rahimi, M. T. and Barac, A. and Rubino, S. and Zarean, M. and Mathioudakis, A. G. and Cevik, M. (2019) Transfusion-transmitted malaria: A systematic review and meta-analysis. Open Forum Infectious Diseases, 6 (7). pp. 1-8.

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Abstract

Background. Malaria transmission through blood transfusion is an accidental but preventable cause of malaria infection and is increasingly becoming a matter of concern for blood transfusion services. This systematic review was conducted to provide a summary of evidence about the prevalence of Plasmodium infection in asymptomatic blood donors and the effectiveness of screening methods used based on the available literature. Methods. PRISMA guidelines were followed. Scopus, PubMed, Science Direct, and EMBASE were searched from 1982 to October 10, 2017. All peer-reviewed original research articles describing the prevalence of malaria parasitemia in blood donors with different diagnostic methods were included. The random-effects model was applied to assess the effects of heterogeneity among the selected studies. Incoherence and heterogeneity between studies were quantified by I2 index and Cochran's Q test. Publication and population bias was assessed with funnel plots and Egger's regression asymmetry test. All statistical analyses were performed using Stata (version 2.7.2). Results. Seventy-one studies from 21 countries, 5 continents, were included in the present systematic review. The median prevalence of malaria parasitemia among 984 975 asymptomatic healthy blood donors was 10.54, 5.36, and 0.38 by microscopy, molecular methods (polymerase chain reaction), and rapid diagnostic tests, respectively. The most commonly detected Plasmodium species was P. falciparum. Conclusions. This systematic review demonstrates that compared with other transfusion-linked infections, that is, HIV, HCV, and HBV, transfusion-transmitted malaria is one of the most significant transfusion-associated infections especially in Sub-Saharan Africa. Future work must aim to understand the clinical significance of transfusion-transmitted malaria in malaria-endemic settings. © The Author(s) 2019.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Ahmadpour, E.; Department of Parasitology and Mycology, Tabriz University of Medical Sciences, PO Box: 14155-6446, Iran; email: ehsanahmadpour@gmail.com
Uncontrolled Keywords: Blood donor Plasmodium Systematic review Transfusion medicine Transfusion-associated infections diagnostic procedure human malaria meta analysis Plasmodium falciparum polymerase chain reaction Preferred Reporting Items for Systematic Reviews and Meta-Analyses prevalence priority journal Review risk factor
Subjects: QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 20 Jun 2020 09:30
Last Modified: 20 Jun 2020 09:30
URI: http://eprints.mums.ac.ir/id/eprint/18234

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