The effects of curcumin on weight loss among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials

Akbari, M. and Lankarani, K. B. and Tabrizi, R. and Ghayour-Mobarhan, M. and Peymani, P. and Ferns, G. and Ghaderi, A. and Asemi, Z. (2019) The effects of curcumin on weight loss among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials. Frontiers in Pharmacology, 10 (JUN).

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Abstract

Background and objective: The current systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out to assess the influence of curcumin intake on weight among patients with metabolic syndrome and related disorders. Methods: We searched the following databases up until January 2018: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The relevant data were extracted and evaluated for quality of the studies in accordance with the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as standardized mean difference (SMD) with 95 confidence intervals (95 CI). Results: Eighteen articles (21 studies) that comprised a total of 1,604 individuals were finally included in the meta-analysis. Curcumin intake significantly reduced body mass index (BMI) (SMD −0.37; 95 CI, −0.61, −0.13; P < 0.01), weight (SMD −0.23; 95 CI, −0.39, −0.06; P < 0.01), waist-circumference (WC) (SMD −0.25; 95 CI, −0.44, −0.05; P = 0.01), leptin levels (SMD −0.97; 95 CI, −1.18, −0.75; P < 0.001) and increased adiponectin levels (SMD 1.05; 95 CI, 0.23, 1.87; P = 0.01). We found no significant effect of curcumin intake on hip ratio (HR) (SMD −0.17; 95 CI, −0.42, 0.08; P = 0.18). Conclusions: Overall, we have found that curcumin intake among patients with metabolic syndrome and related disorders was correlated with a significant reduction in BMI, weight, WC, and leptin, and a significant increase in adiponectin levels, but did not affect HR. Copyright © 2019 Akbari, Lankarani, Tabrizi, Ghayour-Mobarhan, Peymani, Ferns, Ghaderi and Asemi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Correspondence Address: Asemi, Z.; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical SciencesIran; email: asemir@yahoo.com
Uncontrolled Keywords: BMI Curcumin Leptin Meta-analysis Weight loss adipocytokine adiponectin body composition body mass body weight loss childhood obesity comorbidity disease association human hyperlipidemia meta analysis metabolic syndrome X non insulin dependent diabetes mellitus nonalcoholic fatty liver protein blood level randomized controlled trial (topic) Review systematic review therapy effect treatment duration waist circumference waist hip ratio
Subjects: WD Nutrition Disease and metabolic diseases
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 20 Jun 2020 09:27
Last Modified: 20 Jun 2020 09:27
URI: http://eprints.mums.ac.ir/id/eprint/18237

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