Assessment of serum levels of iron and zinc in children with ADHD compared to healthy controls: A case-control study

Avval, F. Z. and Soltanifar, A. and Moharreri, F. and Kamrani, M. and Rad, M. M. M. (2019) Assessment of serum levels of iron and zinc in children with ADHD compared to healthy controls: A case-control study. Iranian Journal of Psychiatry and Behavioral Sciences, 13 (3).

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Abstract

Background: Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent psychiatric disorders in both developed and developing countries. Deficiency of vital elements such as iron and zinc is thought to interrupt the function of dopaminergic pathways. Objectives: This study aimed to assess the serum levels of iron and zinc among children with ADHD who referred to a psychiatric clinic in Mashhad, compared to healthy controls. Methods: This case-control study was conducted on 51 subjects (36 ADHD cases and 15 healthy controls) aged 6 - 12 years. The serum levels of ferritin and zinc, total iron-binding capacity (TIBC), and hemoglobin were assessed and compared between the groups. P values of less than 0.05 were considered statistically significant. Results: The mean age was 7.8 ± 2.12 and 8.4 ± 3.11 years in ADHD and control children, respectively. There were significant differences between the groups regarding mean corpuscular volume (MCV) (P = 0.003), mean corpuscular hemoglobin concentration (MCHC) (P = 0.002), and zinc level (P = 0.015). However, no significant difference was observed in hemoglobin, iron, TIBC, and ferritin between the two groups (P > 0.05). Conclusions: The levels of serum iron and ferritin did not differ significantly between children with and without ADHD. Surprisingly, we found the serum zinc level to be higher inADHDchildren than in healthy controls. Further studies with larger sample sizes are needed to draw reliable conclusions. © 2019, Author(s).

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Soltanifar, A.; Psychiatry and Behavioral Research Center, Mashhad University of Medical SciencesIran; email: soltanifara@mums.ac.ir
Uncontrolled Keywords: Attention Deficit Hyperactivity Disorder DSM-IV-TR criteria Ferritin Iron Zinc hemoglobin Article attention deficit disorder case control study child controlled study female ferritin blood level hemoglobin blood level human iron binding capacity iron blood level major clinical study male mean corpuscular hemoglobin mean corpuscular volume mental hospital pilot study zinc blood level
Subjects: WM Psychiatry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 20 Jun 2020 09:23
Last Modified: 20 Jun 2020 09:23
URI: http://eprints.mums.ac.ir/id/eprint/18266

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