Association between gastric lymphoid follicles (Precursor of malt lymphomas) and h. pylori infection at a referral hospital in Iran

Bashiri, H. and Esmaeilzadeh, A. and Vossoughinia, H. and Ghaffarzadegan, K. and Raziei, H. R. and Bozorgomid, A. (2019) Association between gastric lymphoid follicles (Precursor of malt lymphomas) and h. pylori infection at a referral hospital in Iran. Clinical and Experimental Gastroenterology, 12. pp. 409-413.

[img] Text
Association between gastric lymphoid follicles (Precursor of malt lymphomas) and h. pylori infection at a referral hospital in Iran.pdf

Download (200kB)

Abstract

Purpose: Mucosa-associated lymphoid tissue (MALT) is the most common endoscopic finding in Helicobacter pylori positive patients that can progress to MALT lymphoma after a prolonged antigenic contact. This study was aimed to evaluate the prevalence of lymphoid follicles and aggregates (precursors of MALT lymphomas) in gastric mucosal biopsies and their correlation with H. pylori infection. Patients and methods: In this study, 100 patients who had undergone an upper gastrointestinal endoscopy were enrolled. Five biopsy specimens were taken each patient through screening endoscopy and histopathological changes were evaluated and graded using the Wotherspoon System. The clinical background and H. pylori infection status were also investigated. Results: Among the 100 cases in our series, 79 patients (79) showed evidence of MALT in at least one biopsy specimen taken from the stomach and 21 cases (21) had no evidence of MALT. H. pylori infection was detected in 74 (74) patients. Lymphoid follicles were detected more frequently in H. pylori-positive patients (59) compared to H. pylori-negative cases (3) (P<0.001). Conclusion: The frequency of lymphoid follicles and aggregates in gastric mucosal is associated with H. pylori infection. Further community-based studies in larger sample sizes using a combination of microscopic methods and PCR assay are required for effective monitoring of H. pylori infection. © 2019 Bashiri et al.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Bozorgomid, A.; Infectious Diseases Research Center, Kermanshah University of Medical SciencesIran; email: arezoobozorgomid@yahoo.com
Uncontrolled Keywords: Gastritis Helicobacter pylori Lymphoid aggregate Lymphoid follicle adult Article bacterial clearance cancer screening clinical evaluation controlled study correlational study cross-sectional study disease association female gastrointestinal biopsy gastrointestinal endoscopy Helicobacter infection human human tissue Iran lymph follicle major clinical study male marginal zone lymphoma nonhuman prevalence quality of life
Subjects: WI Digestive System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 20 Jun 2020 09:06
Last Modified: 20 Jun 2020 09:06
URI: http://eprints.mums.ac.ir/id/eprint/18284

Actions (login required)

View Item View Item