Ischemic colitis due to antiphospholipid antibody syndrome

Choobi Anzali, B. and Bahreini, M. and Habibi, B. and Sharifi Sistani, N. (2019) Ischemic colitis due to antiphospholipid antibody syndrome. Turkish Journal of Emergency Medicine, 19 (1). pp. 36-38.

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Introduction: Portal system ischemia may present insidiously which may aggravates the prognosis. Case presentation: A 26-year old man presented with watery diarrhea and generalized abdominal pain for 3 months. On physical examination, moderate splenomegaly was noticeable. Stool exam and culture was negative except for blood in stool. Colonoscopy was in favor of inflammatory bowel disease although the patient symptoms have worsened despite treatment. Abdominopelvic computed tomography (CT) showed thromboses in portal and superior mesenteric veins and as the ill patient evolved signs of peritonitis, he underwent laparotomy during which, total colectomy was performed due to significant bowel necrosis. The cause of venous thrombosis of the portal system revealed to be Factor V Leiden and the presence of antiphospholipid syndrome. Conclusion: High mortality rates of portal and mesenteric thromboses despite therapy urge the need for early clinical suspicion, careful assessment of the differential diagnoses and timely treatment for fewer adverse events. Although the therapeutic plan is challenging, anticoagulation, angiography and surgical resection increase survival. © 2019 Emergency Medicine Association of Turkey

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Bahreini, M.; Department of Emergency Medicine, Tehran University of medical SciencesIran; email:
Uncontrolled Keywords: Antiphospholipid syndrome Factor V Leiden Inflammatory bowel disease Portal vein Splenic vein Thrombosis antibiotic agent blood clotting factor 5 Leiden fibrin degradation product fibrinogen fresh frozen plasma mesalazine abdominal pain abdominal tenderness adult Article ascites blood smear bloody diarrhea case report chronic gastritis clinical article colon biopsy colonoscopy computer assisted tomography diarrhea Doppler flowmetry dyspnea fever gastrointestinal endoscopy histopathology human human tissue hypotension intestine necrosis ischemic colitis laparotomy male nausea peritonitis physical examination splenomegaly thrombocytopenia total colon resection vein thrombosis vomiting
Subjects: WB Practice of Medicine
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 05:06
Last Modified: 21 Jun 2020 05:06

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