Flavonoids from the aerial parts of Artemisia biennis Willd

Dehmoradkhani, K. R. and Jafari, A. and Shokoohinia, Y. and Emami, S. A. and Mojarrab, M. (2019) Flavonoids from the aerial parts of Artemisia biennis Willd. Pharmaceutical Sciences, 25 (4). pp. 364-368.

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Background: The current phytochemical study was carried out on a fraction of dried polar extract of aerial parts of Artemisia biennis Willd. which was previously reported to decrease the viability of the rat pheochromocytoma cell line PC12 in cell-based antioxidant assays. Methods: A combination of solid phase extraction (SPE) and high pressure liquid chromatography (HPLC) of the hydroethanolic extract was used to purify the compounds. Structures of the isolated compounds were elucidated by spectroscopic means, including 1H-NMR and MS analyses. Results: Three isolated and identified flavonoids in this study were luteolin, kaempferol and apigenin. Conclusion: The cytotoxic potential of flavone aglycones, as the major components of selected fraction in the hydroethanolic extract of A. biennis might partly be related to the high death rate of PC12 cells. © 2019 The Authors. This is an open access article and applies the Creative Commons Attribution (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, as long as the original authors and source are cited. No permission is required from the authors or the publishers.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Mojarrab, M.; Pharrmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical SciencesIran; email: mmojarrab@kums.ac.ir
Uncontrolled Keywords: Apigenin Artemisia biennis Kaempferol Luteolin PC12 cell line Artemisia biennis extract flavonoid plant extract unclassified drug aerial plant part animal cell antioxidant assay Artemisia Article drug isolation drug structure high performance liquid chromatography mass spectrometry nonhuman PC12 cell line (pheochromocytoma) proton nuclear magnetic resonance rat solid phase extraction
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 05:09
Last Modified: 21 Jun 2020 05:09
URI: http://eprints.mums.ac.ir/id/eprint/18308

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