Transcriptional Analysis of Lennert Lymphoma Reveals a Unique Profile and Identifies Novel Therapeutic Targets

Etebari, M. and Navari, M. and Agostinelli, C. and Visani, A. and Peron, C. and Iqbal, J. and Inghirami, G. and Piccaluga, P. P. (2019) Transcriptional Analysis of Lennert Lymphoma Reveals a Unique Profile and Identifies Novel Therapeutic Targets. Frontiers in Genetics, 10.

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Abstract

Lennert lymphoma (LL) is a lymphoepithelioid morphological variant of peripheral T-cell lymphoma—not otherwise specified (PTCL/NOS), clinically characterized by better prognosis if compared with other PTCL/NOS. Although well characterized as far as morphology and phenotype are concerned, very little is known regarding its molecular features. In this study, we investigated the transcriptional profile of this tumor aiming 1) to identify its cellular counterparts; 2) to better define its relation with other PTCLs—and, therefore, its possible position in lymphoma classification; and 3) to define pathogenetic mechanisms, possibly unveiling novel therapeutic targets. To address these issues, we performed gene and microRNA expression profiling on LL and other PTCL/NOS cases; we identified different genes and microRNAs that discriminated LL from other PTCL/NOS. Particularly, LL revealed a molecular signature significantly enriched in helper function and clearly distinguishable from other PTCL/NOS. Furthermore, PI3K/Akt/mTOR pathway emerged as novel potential therapeutic target. In conclusion, based on the already known particular morphological and clinical features, the new molecular findings support the hypothesis that LL might be classified as a separate entity. Preclinical and clinical studies testing the efficacy of PI3K/MTOR inhibitors in this setting are warranted. © Copyright © 2019 Etebari, Navari, Agostinelli, Visani, Peron, Iqbal, Inghirami and Piccaluga.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Piccaluga, P.P.; Department of Experimental, Diagnostic, and Specialty Medicine, Bologna University Medical SchoolItaly; email: pierpaolo.piccaluga@unibo.it
Uncontrolled Keywords: gene expression profiling Lennert lymphoma miRNA profiling peripheral T-cell lymphoma—not otherwise specified WHO classification CD68 antigen granzyme B microRNA nucleolysin TIA 1 isoform p40 STAT1 protein STAT5 protein transcription factor FOXP3 adolescent adult aged Akt signaling Article bioinformatics cancer staging CD4+ T lymphocyte child cytotoxic T lymphocyte female gene expression hemophagocytic syndrome human human tissue immune response immunohistochemistry lymphoma macrophage major clinical study male morphology peripheral T cell lymphoma phenotype real time polymerase chain reaction T cell lymphoma Tfh cell tissue microarray upregulation
Subjects: QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 05:11
Last Modified: 21 Jun 2020 05:11
URI: http://eprints.mums.ac.ir/id/eprint/18321

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