Vaso-nervorumitis: Responsible for pain in Buerger’s disease?

Fazeli, B. and Farzadnia, M. and Taheri, H. (2019) Vaso-nervorumitis: Responsible for pain in Buerger’s disease? International Medical Case Reports Journal, 12. pp. 119-123.

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Buerger’s disease (BD) is an episodic, inflammatory, and occlusive peripheral vascular disease with unknown etiology, which can lead to tissue or limb loss. BD patients usually present neurological symptoms from the early stages of the disease including numbness, cold sensation, and allodynia as the disease progresses. Pain in the late stages of BD is very severe, almost resistant to opioid pain killers, and sometimes compels the patient to pursue major amputation. Therefore, pain management in BD patients is one of the most important and, at the same time, challenging issues since its main etiology is not well understood. Recently, a 39-year-old male smoker with a diagnosis of BD underwent a belowknee amputation in his left leg. Oddly, we found that the vasa-nervorum of the sural nerve had the pathological changes usually observed in BD, including inflammation and proliferation of endothelial cells. Notably, the inflammation was limited to the vasa-nervorum and did not extend to the nerve fascicles. Our findings could provide a clue to taking the approach of managing pain in BD as if it were vasculitis neuropathy; and the inflammation of the vasanervorum individually might be responsible for the pain characteristic of BD. In addition, our findings could indicate that BD is a systemic vasculitis of microcirculation and, hence, a different treatment approach for BD might be needed in addition to antithrombotic and vasodilator. © 2019 Fazeli et al.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Fazeli, B.; Immunology Research Center, Inflammation and Inflammatory Diseases Division, School of Medicine, Medical Faculty, Mashhad University of Medical Sciences, Pardis Campus, Azadi Sqr, Iran; email:
Uncontrolled Keywords: Buerger’s disease Pain Pathophysiology Thromboangiitis obliterans Vasa-nervorum acetylsalicylic acid alprostadil alfadex cilostazol clindamycin ofloxacin pregabalin silver nanoparticle adult analgesia artery occlusion Article below knee amputation biopsy technique Buerger disease case report Caucasian clinical article clinical feature computed tomographic angiography foot pain foot ulcer gangrene human human tissue laboratory test male neuropathy pain severity physical examination prescription smoking cessation superficial femoral artery superficial thrombophlebitis sural nerve toe vasa nervorum vasculitis
Subjects: QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 05:10
Last Modified: 21 Jun 2020 05:10

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