Screening for Celiac Disease Using Anti Tissue Transglutaminase in Patients with Esophageal SCC between 2004 and 2009

Vosoughinia, Hasan and AleDavood, Seyed Amir and Ghaffarzadehgan, Kamran and shakeri, Mohammadtaghi and Sharifan, Ramin and Abedini, Siavosh and Mokhtari Amirmajdi, Elham (2015) Screening for Celiac Disease Using Anti Tissue Transglutaminase in Patients with Esophageal SCC between 2004 and 2009. Journal of Cardio-Thoracic Medicine, 3 (1). pp. 254-258.

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 Introduction: Esophageal Squamous-Cell Carcinoma (SCC) is one of the most common malignancies in Iran. To reduce the incidence of esophageal SCC, it is important to recognize the controllable risk factors and prevent them. Celiac disease is widely known as a possible risk factor for esophageal SCC. Thus, we decided to assess the frequency of celiac disease in esophageal SCC patients in North east of Iran in order to suggest correlation between two diseases. Materials and Methods: In a Cross-sectional study one hundred and forty-three cases of esophageal SCC were examined for anti tissue transglutaminase antibody (anti-tTG) between the years 2004 and 2009 in Ghaem and Omid Hospitals of Mashhad University of Medical Sciences, Iran. The enzyme-linked immunosorbent assay was the test of choice in this study since it provides the sensitivity and specificity needed for the diagnosis and screening of celiac disease. The results of this test were compared with those of the control group which were compatible in terms of sex and age. Data were analyzed through SPSS software and statistical analysis such as x2, exact x2 and T-test. Results:19.6 patients (SCC) had positive anti-tTG (>20) which was significantly different to 7.9 in control group (p -value=0.005). Comparing age groups of patients for positive antitTG using exact x square test showed significant difference in patients with Conclusion: There seems to be a correlation between positive antitTG and esophageal SCC; that is to say, celiac disease might play a role in the earlier manifestations of esophageal SCC.

Item Type: Article
Subjects: WF Respiratory System
WO Surgery
Divisions: Journals > J Cardio-Thoracic Medicine
Depositing User: jctm jctm
Date Deposited: 20 Sep 2017 15:04
Last Modified: 20 Sep 2017 15:04

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