Tissue composition effect on dose distribution in radiotherapy with a 6 MV photon beam of a medical linac

Ghorbani, M. and Noghreiyan, A. and Tabatabaei, Z. and Pakravan, D. and Davenport, D. (2019) Tissue composition effect on dose distribution in radiotherapy with a 6 MV photon beam of a medical linac. Journal of Cancer Research and Therapeutics, 15 (1). pp. 237-244.

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Abstract

Aim: The aim of this study is to evaluate soft-tissue composition effect on dose distribution for various soft tissues in radiotherapy with a 6 MV photon beam of a medical linac. Background: The compositions of various soft tissues are different which could affect dose calculations. Materials and Methods: A phantom and Siemens Primus linear accelerator were simulated using MCNPX Monte Carlo code. In a homogeneous cubic phantom, six types of soft tissue and three types of tissue-equivalent materials were defined separately. The soft tissues were muscle (skeletal), adipose tissue, blood (whole), breast tissue, soft tissue (9-component), and soft tissue (4-component). The tissue-equivalent materials included water, A-150 tissue equivalent plastic and perspex. Photon dose relative to dose in 9-component soft tissue at various depths on the beam's central axis was determined for the 6 MV photon beam. The relative dose was also calculated and compared for various MCNPX tallies including ∗F8, F6, and ∗F4. Results: The results of the relative photon dose in various materials relative to dose in 9-component soft tissue using different tallies are reported in the form of tabulated data. Minor differences between dose distributions in various soft tissues and tissue-equivalent materials were observed. The results from F6 and F4 were practically the same but differ with the ∗F8 tally. Conclusions: Based on the calculations performed, the differences in dose distributions in various soft tissues and tissue-equivalent materials are minor but they could be corrected in radiotherapy calculations to upgrade the accuracy of the dosimetric calculations. © 2019 Journal of Cancer Research and Therapeutics | Published by Wolters Kluwer - Medknow.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Noghreiyan, A.; Studen. Research Committee, Faculty of Medicine, Mashhad University of Medical SciencesIran; email: vejdania931@mums.ac.ir
Uncontrolled Keywords: Dose distribution photon beam radiotherapy tissue composition adipose tissue Article breast tissue dosimetry photon therapy radiation dose distribution skeletal muscle soft tissue devices drug therapy human imaging phantom magnetic and electromagnetic equipment Monte Carlo method neoplasm organs at risk photon procedures radiation response radiometry radiotherapy dosage radiotherapy planning system Humans Neoplasms Particle Accelerators Phantoms, Imaging Photons Radiotherapy Planning, Computer-Assisted
Subjects: QT physiology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 06:30
Last Modified: 21 Jun 2020 06:30
URI: http://eprints.mums.ac.ir/id/eprint/18367

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