Successful treatment by adding thalidomide to meglumine antimoniate in a case of refractory anthroponotic mucocutaneous leishmaniasis

Goyonlo, V. M. and Vahabi-Amlashi, S. and Taghavi, F. (2019) Successful treatment by adding thalidomide to meglumine antimoniate in a case of refractory anthroponotic mucocutaneous leishmaniasis. International Journal for Parasitology: Drugs and Drug Resistance, 11. pp. 177-179.

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Abstract

Mucosal leishmaniasis (ML) is mostly associated with Leishmania braziliensis; however, a few cases of Leishmania tropica induced mucocutaneous leishmaniasis have been reported. The standard treatment for leishmaniasis is pentavalent antimonials, but several other drugs for resistant cases have been proposed including amphotericin and miltefosine. Here we present a case of multiple treatment resistant mucocutaneous leishmaniasis with nasal involvement caused by L. tropica; cure was not achieved by multiple treatments and was eventually improved by adding thalidomide to Meglumine Antimoniate (Glucantime). To the best of our knowledge use of thalidomide in humans for leishmaniasis treatment is reported here for the first time. © 2019 The Authors

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Vahabi-Amlashi, S.; Department of Dermatology, Faculty of Medicine, Mashhad University of Medical SciencesIran; email: VahabiS@mums.ac.ir
Uncontrolled Keywords: Leishmania tropica Mucocutaneous Leishmaniasis Thalidomide amphotericin B amphotericin B deoxycholate meglumine antimonate miltefosine adult Article case report clinical article dyspnea excision human immunocompetence laboratory test male nose disease polymerase chain reaction priority journal skin leishmaniasis snoring x-ray computed tomography young adult
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 06:30
Last Modified: 21 Jun 2020 06:30
URI: http://eprints.mums.ac.ir/id/eprint/18376

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