Improvement of fertility parameters with Tribulus Terrestris and Anacyclus Pyrethrum treatment in male rats

Haghmorad, D. and Mahmoudi, M. B. and Haghighi, P. and Alidadiani, P. and Shahvazian, E. and Tavasolian, P. and Hosseini, M. and Haghmorad, M. M. D. and Mahmoudi, M. B. and Haghighi, P. and Alidadiani, P. and Shahvazian, E. and Tavasolian, P. and Hosseini, M. and Mahmoudi, M. (2019) Improvement of fertility parameters with Tribulus Terrestris and Anacyclus Pyrethrum treatment in male rats. International Braz J Urol, 45 (5). pp. 1043-1054.

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Abstract

Objective: Anacyclus Pyrethrum (AP) and Tribulus Terrestris (TT) have been reported as male infertility treatment in several studies; however, in Iranian traditional medicine these two plants are prescribed simultaneously. In this study, we aimed to determine the effects of AP and TT extracts both separately and simultaneously on the male Wistar rat fertility parameters. Materials and Methods: 32 male Wistar rats were divided into 4 groups: Control, TT, AP, and AT treated groups. Treatment continued for 25 days and rats were weighed daily. Their testes were dissected for histological studies. Sperm analysis including sperm count, viability and motility were performed. Serum was obtained to evaluate testosterone, LH and FSH levels. Histological studies were conducted to study Leydig, and Sertoli cells, spermatogonia and spermatid cell numbers, and to measure seminiferous diameter and epithelium thickness. Results: Sperm count increased in all the treatment groups. Sperm viability and motility in AT and AP groups were elevated. TT and AT groups showed significantly increased testosterone level compared to control group (P=004, P=0.000, respectively) and TT, AP and AT treatment groups showed increased LH level (P=0.002, P=0.03 and P=0.000, respectively) compared to control, while only AT group showed increased FSH (p=0.006) compared to control. Histological studies showed significant increase of spermatogonia, Leydig and Sertoli cell numbers and epithelial thickness in AT group compared to other groups. All the treatment groups had higher number of Leydig, spermatogonia and spermatid cells. Conclusion: TT and AP improved sexual parameters; however, their simultaneous administration had higher improving effects on studied parameters. © 2019, Brazilian Society of Urology.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 CODEN: IBJUA Correspondence Address: Mahmoudi, M.; Immunology Research Center, BuAli Research Institute, Department of Immunology and Allergy, School of Medicine, Mashhad University of Medical SciencesIran; email: mahmoudim@mums.ac.ir
Uncontrolled Keywords: FSH LH Receptors Testosterone Tribulus follitropin luteinizing hormone plant extract animal blood body weight chemistry drug effect evaluation study fertility human male male infertility organ size pyrethrum reference value reproducibility spermatozoon spermatozoon count spermatozoon motility testis treatment outcome Wistar rat Animals Chrysanthemum cinerariifolium Follicle Stimulating Hormone Humans Infertility, Male Plant Extracts Rats, Wistar Reference Values Reproducibility of Results Sperm Count Sperm Motility Spermatozoa
Subjects: QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 06:32
Last Modified: 21 Jun 2020 06:32
URI: http://eprints.mums.ac.ir/id/eprint/18383

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