Common variations in prothrombotic genes and susceptibility to ischemic stroke in young patients: A case-control study in southeast Iran

Hashemi, S. M. and Ramroodi, N. and Fard, H. A. and Talebian, S. and Rohani, M. H. and Rezaei, M. and Noora, M. and Salimi, S. (2019) Common variations in prothrombotic genes and susceptibility to ischemic stroke in young patients: A case-control study in southeast Iran. Medicina (Lithuania), 55 (2).

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Abstract

Background and Objective: Evidence indicates that genetic factors may be involved in the risk of ischemic stroke (IS). The aim of this study was to assess the effect of genetic polymorphisms located in exons or untranslated regions of MTHFR as well as FV genes on ischemic stroke. Materials and Methods: In this case-control study, 106 patients with IS and 157 healthy volunteers (age <50 years) were genotyped for MTHFR C677T, A1298C, C2572A and C4869G, FVL, and prothrombin G20210A polymorphisms. Results: The MTHFR 677CT genotype was more frequent in patients and increased risk of IS with Odds Ratio = 1.9. The MTHFR A1298C and C2572A polymorphisms were not associated with IS in dominant and recessive models. Our findings showed a significant decrease in the MTHFR 4869CG genotype in IS patients, and this variant was associated with a decreased risk of IS in the dominant model. The CAAT haplotype was associated with increased risk, and the GAAC haplotype was associated with decreased risk of IS compared to other haplotypes. There was no relation between FVL G1691A polymorphism and IS risk. Conclusions: The present study showed that the MTHFR 677CT genotype was more frequent and the MTHFR 4869CG genotype was less frequent in young IS patients. © 2019, MDPI AG. All rights reserved.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Salimi, S.; Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical SciencesIran; email: sasalimi@yahoo.com
Uncontrolled Keywords: Factor V Ischemic stroke MTHFR Polymorphism Prothrombin blood clotting factor 5 methylenetetrahydrofolate reductase (NADPH2) MTHFR protein, human adult brain ischemia case control study female gene frequency genetic polymorphism genetic predisposition genetics genotype haplotype human Iran male middle aged nonparametric test questionnaire risk statistical model Case-Control Studies Genetic Predisposition to Disease Haplotypes Humans Logistic Models Polymorphism, Genetic Statistics, Nonparametric Surveys and Questionnaires
Subjects: QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 06:36
Last Modified: 21 Jun 2020 06:36
URI: http://eprints.mums.ac.ir/id/eprint/18402

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