A study of the main determinants of kidney allograft long-term survival in the era of new immunosuppressive drugs

Hekmat, R. and Sturdevant, M. (2019) A study of the main determinants of kidney allograft long-term survival in the era of new immunosuppressive drugs. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 30 (3). pp. 640-647.

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Abstract

The outcome of long-term kidney allograft is extremely important. The present study aimed to discern the factors affecting long-term kidney allograft survival, including the type of donation and the use of extended criteria donors. Seven hundred and thirty-seven kidney transplant alone patients entered this retrospective cross-sectional study. The impact of different factors on death-censored long-term kidney allograft survival was evaluated. The Cox proportional survival model was employed to identify these factors. A value of P < 0.05 was considered statistically significant. The data were analyzed using IBM Statistical Package for the Social Sciences version 19.0. The study was conducted at the Mashhad University of Medical Sciences, Mashhad, Iran. In comparison with living kidney donations, both nontraumatic and traumatic brain death cadaveric kidney donations showed statistically significant inferior graft survival. Furthermore, the Kaplan-Meier survival analysis showed better durability of living kidney donations in comparison with traumatic and nontraumatic deceased donors (Log-rank test value = 0.001). Patients with delayed graft function (DGF) had a significantly shorter long-term death censured long-term graft survival in comparison with those without this complication. The Cox proportional models showed that DGF occurrence and the type of donation play a statistically significant role in long-term kidney graft survival. In addition, regarding graft survival, there was no difference between standard criteria and extended criteria donors. The occurrence of DGF and living or deceased types of donations have a significant effect on long-term kidney allograft survival.

Item Type: Article
Additional Information: Export Date: 16 February 2020
Uncontrolled Keywords: immunosuppressive agent adult adverse event aged cross-sectional study delayed graft function drug effect female graft rejection graft survival human immunology kidney transplantation living donor male middle aged mortality retrospective study risk assessment risk factor time factor treatment outcome Cross-Sectional Studies Humans Immunosuppressive Agents Living Donors Retrospective Studies Risk Factors Time Factors
Subjects: WJ Urogenital System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 06:44
Last Modified: 21 Jun 2020 06:44
URI: http://eprints.mums.ac.ir/id/eprint/18411

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