Investigation of the relationship between atopy and psoriasis

Hosseini, P. and Khoshkhui, M. and Hosseini, R. F. and Ahanchian, H. and Ravanshad, Y. and Layegh, P. and Bakhshoudeh, B. and Ariaee, N. (2019) Investigation of the relationship between atopy and psoriasis. Postepy Dermatologii i Alergologii, 36 (3). pp. 276-281.

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Abstract

Introduction: The relationship between allergic and autoimmune diseases is an important issue, which has recently attracted the researchers’ interest. Aim: To determine the relationship between atopy and psoriasis. Material and methods: This case-control study was conducted on 102 patients referred to the Ghaem Hospital, Mashhad, Iran, in 2016. The participants were assigned into two groups: experimental and control groups, including the patients suffering from psoriasis and those with no history of cutaneous or other systemic diseases, respectively. Both groups filled in the ISAAC questionnaire and had skin prick tests. In addition, the serum levels of immunoglobulin E (IgE) and blood eosinophil cell count were measured. The data were analysed using the regression test through SPSS version 16. Results: According to the results of the ISAAC questionnaire, there was a significant difference between the control and experimental groups in terms of asthma (p = 0.04). The mean serum concentrations of IgE and eosinophil cell count were not significantly different between the experimental (153.93 IU/ml and 187.77 cells/μl, respectively) and control groups (152.19 IU/ml and 187.68 cells/μl, respectively) (p = 0.057 and p = 0.886, respectively). In addition, there was an indirect correlation between the eosinophil cell count and psoriasis severity (p = 0.032, r = –0.297). Furthermore, the comparison of the skin prick test results revealed no significant difference between the two groups regarding the number of positive and negative cases (p = 0.436). Conclusions: The findings suggested that atopy was not common in the patients with psoriasis and supported the concept that atopy protects against such autoimmune diseases such as psoriasis. © 2019 Termedia Publishing House Ltd. All rights reserved.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Khoshkhui, M.; Allergy Research Center, Mashhad University of Medical Sciences, Ghaem Hospital, Shariati Square, Iran; email: khoshkhuim@mums.ac.ir
Uncontrolled Keywords: Atopy Eosinophilia Immunoglobulin E Psoriasis allergen adult allergic rhinitis Article asthma atopic dermatitis case control study comparative study controlled study disease association disease duration eczema eosinophil count female human immunoglobulin blood level major clinical study male prick test Psoriasis Area and Severity Index psoriasis vulgaris questionnaire
Subjects: QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 06:42
Last Modified: 21 Jun 2020 06:42
URI: http://eprints.mums.ac.ir/id/eprint/18416

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