The polymorphism of XRCC1 Arg399Gln (rs25487) and male infertility risk: A meta-analysis of 1,407 cases and 974 control studies

Ibrahimi, R. and Musavi, M. and Shojaee, M. and Moossavi, M. and Moossavi, S. Z. and Alaei, M. and Poodineh, J. and Ibrahimi, M. and Farahani, Y. and Khorasani, M. (2019) The polymorphism of XRCC1 Arg399Gln (rs25487) and male infertility risk: A meta-analysis of 1,407 cases and 974 control studies. Bratislava Medical Journal, 120 (5). pp. 349-355.

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Abstract

X-ray repair cross-complementing group 1 (XRCC1) is a scaffold protein and a key element in DNA base excision repair process. Although, the role of XRCC1 polymorphisms in male infertility has been studied broadly, it is still a matter of debate. Hence, in order to shed light on the problem, we performed a meta-analysis to evaluate the overall effect of XRCC1 polymorphisms in male infertility risk. Databases, Web of Science, PubMed, Scopus, and Google Scholar were searched until September 15, 2018. Afterwards, the genotypes' distribution, genotyping methods, and ethnicity groups were extracted, and overall analyses were conducted. A total number of five researches on 1,407 subjects and 974 controls were found to meet our criteria in this meta-analysis. The XRCC1 Arg399Gln (rs25487) polymorphism was analyzed. This is the first meta-analysis to investigate the association of XRCC1 polymorphisms (codon 399) and male infertility risk. Our results indicated that the XRCC1 Arg399Gln polymorphism was not associated with male infertility risk in the total studied populations. © AEPress s.r.o.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Khorasani, M.; Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares UniversityIran; email: milad.kh@mofares.ac.ir
Uncontrolled Keywords: Male infertility Meta-analysis Polymorphism XRCC1 Arg399Gln DNA binding protein DNA repair protein XRCC1 XRCC1 protein, human case control study genetic predisposition genetics human male meta analysis risk factor single nucleotide polymorphism Case-Control Studies DNA-Binding Proteins Genetic Predisposition to Disease Humans Infertility, Male Polymorphism, Single Nucleotide Risk Factors X-ray Repair Cross Complementing Protein 1
Subjects: QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 06:42
Last Modified: 21 Jun 2020 06:42
URI: http://eprints.mums.ac.ir/id/eprint/18419

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