Comparison of transforaminal triamcinolone and dexmedetomidine in radicular low-back pain: A randomized double-blind clinical trial

Imani, F. and Rahimzadeh, P. and Khademi, S. H. and Zamanabadi, M. N. and Sadegi, K. and Abolfazli-Karizi, A. (2019) Comparison of transforaminal triamcinolone and dexmedetomidine in radicular low-back pain: A randomized double-blind clinical trial. Anesthesiology and Pain Medicine, 9 (5).

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Abstract

Background: Administration of steroids in the lumbar transforaminal block for lumbar radicular pain is considered one of the preferred treatment methods though it is associated with some complications. Objectives: The effects and side effects of triamcinolone and dexmedetomidine in the lumbar transforaminal block were investigated in the present study. Methods: In this study, 30 patients, aged 40-70 years, suffering from lumbar radicular pain arising from the lumbar disc protrusion were equally divided into two groups of triamcinolone (T) and dexmedetomidine (D). They all underwent lumbar transforaminal blocks. An injection solution of triamcinolone (20 mg) plus ropivacaine (0.2) and another one containing dexmedetomidine (50 µg) plus ropivacaine (0.2) were administered in the triamcinolone and dexmedetomidine groups, respectively. Visual Analog Scale (VAS), Oswestry Disability Index (ODI), Straight Leg Raise (SLR or lasègue’s test), and Fasting Blood Sugar (FBS) were measured at 0, 2 weeks, 1, 3, and 6 months post-procedure. The levels of calcium, magnesium, and vitamin D, as well as potential complications, were also evaluated. Results: Significant differences were found in the VAS and ODI during the measurement times within each group. The VAS and ODI were remarkably different between the dexmedetomidine group and the triamcinolone group. In addition, there were considerable differences in the increased FBS and reduced calcium and vitamin D levels in the triamcinolone group from changes in the dexmedetomidine group. Conclusions: The lumbar transforaminal block with triamcinolone or dexmedetomidine attenuates the lumbar radicular pain. Further, dexmedetomidine exerts a more potent pain relief effect than triamcinolone. © 2019, Author(s).

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Imani, F.; Pain Research Center, Iran University of Medical SciencesIran; email: farnadimani@yahoo.com
Uncontrolled Keywords: Dexmedetomidine Lumbar Radicular Pain Transforaminal Block Triamcinolone paracetamol pregabalin ropivacaine vitamin D adult aged analgesia Article calcium blood level clinical article controlled study female fluoroscopy follow up glucose blood level hemodynamics human low back pain lumbar disk hernia magnesium blood level male nuclear magnetic resonance imaging Oswestry Disability Index radicular pain randomized controlled trial visual analog scale
Subjects: WO Surgery
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 06:36
Last Modified: 21 Jun 2020 06:36
URI: http://eprints.mums.ac.ir/id/eprint/18420

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