Vascular mimicry expression in invasive ductal carcinoma; a new technique for prospect of aggressiveness

Jafarian, A. H. and Kooshkiforooshani, M. and Rasoliostadi, A. and Roshan, N. M. (2019) Vascular mimicry expression in invasive ductal carcinoma; a new technique for prospect of aggressiveness. Iranian Journal of Pathology, 14 (3). pp. 232-235.

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Background & Objective: In vascular (vasculogenic) mimicry (VM), tumoral cells mimic the endothelial cells and form the extracellular matrix-rich tubular networks. It has been proposed that VM is more extensive in aggressive tumors. This study was designed to investigate the rate of VM expression in the stromal cells of invasive ductal carcinoma (IDC) and to find its relationship with other clinicopathological factors. Methods: In this cross-sectional study, 120 patients with histopathologic diagnosis of IDC who received mastectomy were included. The VM expression was determined by immunohistochemistry (IHC). The clinicopathologic data including age, tumor size, histological grade, clinical stage, axillary lymph node metastasis, hormonal receptors, and survival were documented. Results: The mean (±SD) age of the patients was 51 (±13.83) years old. The stromal VM expression was detected in 16 of 120 patients (13.3). Twelve specimens (75) of positive VM expression group had grade 3 which was higher than negative VM expression group (9 cases, 8.65; P<0.001). The VM expression showed statistically significant relationship with higher histologic grade higher clinical stage (stage 3) of the tumor (62.5 vs. 87; P=0.003), the presence of axillary lymph node metastasis (95.6 vs. 55.8; P<0.001), and positive HER-2 (100 vs. 31.1; P<0.001); but not estrogen receptor (ER) or progesterone receptor (PR). However, age, tumor size and mortality rate were not significantly different among the patients with and without VM expression. Conclusion: The stromal VM expression showed significant relationship with higher stage and grade of the tumor and the presence of nodal metastasis. The VM expression in IDC can be used as a marker for tumor aggressiveness. © 2019, Iranian Society of Pathology. All rights reserved.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Roshan, N.M.; Pathology Department, School of Medicine, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: Breast cancer Immunohistochemistry staining Vascular mimicry
Subjects: QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 06:45
Last Modified: 21 Jun 2020 06:45

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