A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by 103Pd seeds

Jangjoo, A. G. and Ghiasi, H. and Mesbahi, A. (2019) A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by 103Pd seeds. Polish Journal of Medical Physics and Engineering, 25 (2). pp. 87-92.

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Abstract

103Pd seed is being used for prostate brachytherapy. Additionally, the dose enhancement effect of gold nanoparticles (GNP) has been reported in previous studies. The aim of this study was to characterize the dosimetric effect of gold nanoparticles in brachytherapy with a 103Pd source. Two brachytherapy seeds including 103 Pd source was simulated using MCNPX Monte Carlo code. The seeds' models were validated by comparing the MC with reported results. Then, GNPs (10 nm in diameter) with a concentration of 7mg Au/g were simulated uniformly inside the prostate of a humanoid computational phantom. Additionally, the dose enhancement factor (DEF) of nanoparticles was calculated for both modeled brachytherapy seeds. A good agreement was found between the MC calculated and the reported dosimetric parameters. For both seeds, an average DEF of 23 was obtained in tumor volume for prostate brachytherapy. The application of GNPs in conjunction with 103Pd seed in brachytherapy can enhance the delivered dose to the tumor and consequently leads to better treatment outcome. © 2019 Amir Ghasemi Jangjoo et al., published by Sciendo 2019.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Ghiasi, H.; Medical Radiation Sciences Research Team, Tabriz University of Medical SciencesIran; email: hoseinghiasi62@gmail.com
Uncontrolled Keywords: 103Pd brachytherapy gold nanoparticle Monte Carlo prostate cancer palladium 103 radioactive seed Article concentration (parameter) dosimetry human Monte Carlo method radiosensitization tumor volume
Subjects: QT physiology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 06:48
Last Modified: 21 Jun 2020 06:48
URI: http://eprints.mums.ac.ir/id/eprint/18436

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