Effect of malva sylvestris extract on postoperative peritoneal adhesion in rats

Jomezadeh, V. and Sheibani, S. and Tavassoli, A. and Karimani, A. and Zirak, M. R. and Mohammadpour, A. H. and Khakzad, M. R. and Afshar, M. and Tavassoli, F. (2019) Effect of malva sylvestris extract on postoperative peritoneal adhesion in rats. Jundishapur Journal of Natural Pharmaceutical Products, 14 (3).

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Abstract

Background: Postoperative peritoneal adhesion occurs in more than 90 of intra-abdominal surgeries and can lead to intestinal obstruction, infertility, abdominal and pelvic pain. The extract of Malva sylvestris has shown to be safe and non-toxic with a wide range of biological activities. Objectives: This study was designed to evaluate the effect of intraperitoneal nebulization of M. sylvestris in the healing process of postoperative intra-abdominal adhesion for the first time. Methods: For creating intra-abdominal adhesions, the rats were anesthetized to undergo surgery. Four lavage solutions including saline, ethanolic extract, hydroalcoholic extract, and aqueous extract of M. sylvestris were used for 2 min, and then the abdomen was closed. After 15 days, the rats underwent surgery and cecum and peritoneal samples were obtained for histopathological analysis. The severity of peritoneal adhesions based on the histopathological analysis and serum levels of TNF-α and Il-1β were compared in different groups. Results: The aqueous and hydroalcoholic extracts of M. sylvestris decreased significantly microscopic and macroscopic peritoneal adhesion while the ethanolic extract just reduced it microscopically. The aqueous and hydroalcoholic extracts were more potent than the ethanolic extract in the healing process. The concentrations of inflammatory biomarkers including Il-1β and TNF-α did not change significantly. Conclusions: The extract of M. sylvestris could decrease the severity of peritoneal adhesion compared to the control group but it could not decrease the level of systemic inflammatory mediators. © 2019, Jundishapur Journal of Natural Pharmaceutical Products.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Tavassoli, F.Emam Reza Sq. Ebne Sina Ave., Iran; email: tavassolif@mums.ac.ir
Uncontrolled Keywords: Malva Peritoneal Fibrosis Peritoneal Lavage Plant Extracts Rats antiinflammatory agent catalase fibrinolytic agent glutathione peroxidase interleukin 1beta Malva sylvestris extract plant extract sodium chloride superoxide dismutase tumor necrosis factor unclassified drug animal experiment Article controlled study drug effect drug synthesis histopathology kidney injury lavage lipid peroxidation male Malva sylvestris nebulization nonhuman peritoneum adhesion postoperative complication rat
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 06:47
Last Modified: 21 Jun 2020 06:47
URI: http://eprints.mums.ac.ir/id/eprint/18438

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