Functionalization and surface modifications of bioactive glasses (BGs): Tailoring of the biological response working on the outermost surface layer

Kargozar, S. and Kermani, F. and Beidokhti, S. M. and Hamzehlou, S. and Verné, E. and Ferraris, S. and Baino, F. (2019) Functionalization and surface modifications of bioactive glasses (BGs): Tailoring of the biological response working on the outermost surface layer. Materials, 12 (22).

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Abstract

Bioactive glasses (BGs) are routinely being used as potent materials for hard and soft tissue engineering applications; however, improving their biological activities through surface functionalization and modification has been underestimated so far. The surface characteristics of BGs are key factors in determining the success of any implanted BG-based material in vivo since they regulate the affinity and binding of different biological macromolecules and thereby the interactions between cells and the implant. Therefore, a number of strategies using chemical agents (e.g., glutaraldehyde, silanes) and physical methods (e.g., laser treatment) have been evaluated and applied to design properly, tailor, and improve the surface properties of BGs. All these approaches aim at enhancing the biological activities of BGs, including the induction of cell proliferation and subsequent osteogenesis, as well as the inhibition of bacterial growth and adhesion, thereby reducing infection. In this study, we present an overview of the currently used approaches of surface functionalization and modifications of BGs, along with discussing the biological outputs induced by these changes. © 2019 by the authors.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Correspondence Address: Kargozar, S.; Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical SciencesIran; email: kargozarsaeid@gmail.com
Uncontrolled Keywords: Bioactive glasses Bioactivity Bone tissue engineering Functionalization Surface modifications Bioactive glass Bone Cell proliferation Surface treatment Tissue Biological macromolecule Biological response Functionalizations Physical methods Soft tissue engineering Surface characteristics Surface Functionalization Tissue engineering
Subjects: QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 06:46
Last Modified: 21 Jun 2020 06:46
URI: http://eprints.mums.ac.ir/id/eprint/18444

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