Using bioactive glasses in the management of burns

Kargozar, S. and Mozafari, M. and Hamzehlou, S. and Baino, F. (2019) Using bioactive glasses in the management of burns. Frontiers in Bioengineering and Biotechnology, 7 (MAR).

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Abstract

The management of burn injuries is considered an unmet clinical need and, to date, no fully satisfactory solution exists to this problem. This mini-review aims to explore the potential of bioactive glasses (BGs) for burn care due to the therapeutic effects of their ionic dissolution products. BGs have been studied for more than 40 years and boast a long successful history in the substitution of damaged tissues, especially bone. Considering their exceptional versatility and attractive characteristics, these synthetic materials have also recently been proposed in the treatment of soft tissue-related disorders such as skin wounds. Specifically, improving fibroblast proliferation, inducing angiogenesis, and eliciting antibacterial activity (with the additional advantage of avoiding administration of antibiotics) are all considered as key added values carried by BGs in the treatment of burn injuries. However, some issues deserve careful consideration while proceeding with the research, including the selection of suitable BG compositions, appropriate forms of application (e.g., BG fibers, ointments or composite patches), as well as the procedures for reliable in vivo testing. © 2019 Kargozar, Mozafari, Hamzehlou and Baino.

Item Type: Article
Additional Information: Cited By :7 Export Date: 16 February 2020 Correspondence Address: Kargozar, S.; Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical SciencesIran; email: kargozarsaeid@gmail.com
Uncontrolled Keywords: Angiogenesis Antibacterial activity Bioactive glasses Burns Ion release Wound healing Cell culture High temperature effects Tissue Anti-bacterial activity Bioactive glass
Subjects: W General medicine- Health professions
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 06:50
Last Modified: 21 Jun 2020 06:50
URI: http://eprints.mums.ac.ir/id/eprint/18446

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