Assessment of T helper 17-associated cytokines in thromboangiitis obliterans

Keramat, S. and Sadeghian, M. H. and Keramati, M. R. and Fazeli, B. (2019) Assessment of T helper 17-associated cytokines in thromboangiitis obliterans. Journal of Inflammation Research, 12. pp. 251-258.

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Background: The management of thromboangiitis obliterans (TAO) remains a medical challenge because of its unknown etiology. It is also not known whether it is a systemic or localized disease or a type of autoimmune vasculitis. Methods: In this study, we evaluated the serum level of IL-17 and IL-23 which increase in both systemic inflammation and autoimmunity, in 60 TAO patients and 30 age- and smoking habit-matched controls. Also, IL-22, which has reported high level during infection but not in autoimmunity, was evaluated. Results: The serum levels of IL-17, IL-22 and IL-23 were significantly higher in the TAO patients in comparison with the controls (P<0.001). Notably, the serum levels of IL-17, IL-22 and IL-23 were highest in the patients with the chief complaint of chronic ulcer and lowest in the patients with gangrene (P<0.05). Also, the serum level of IL-22 was significantly higher in the anemic patients in comparison with the non-anemic patients (P=0.03). Conclusion: Owing to our findings, TAO appears more likely to be a systemic disorder rather than a localized vasculopathy. Therefore, treatment protocols based on systemic treatment of TAO patients may be more helpful than localized treatment, such as bypass surgery and endovascular procedures. Also, according to our findings regarding the high level of IL-22, the trigger of TAO development may be an infectious pathogen. However, additional research is highly recommended to investigate whether TAO is an infectious disease or an infectious-induced autoimmunity. © 2019 Keramat et al.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Fazeli, B.; Immunology Department, Immunology Research Center, Inflammation and Inflammatory Diseases Division, School of Medicine, Mashhad University of Medical Sciences, Pardis Campus, Azadi Sqr, Iran; email:
Uncontrolled Keywords: Autoimmunity Buerger’s disease Interleukin-17 Interleukin-22 Interleukin-23 Thromboangiitis obliterans interleukin 17 interleukin 22 interleukin 23 adult age anemia Article blood cell count blood sampling Buerger disease Caucasian clinical protocol controlled study enzyme linked immunosorbent assay gangrene human infection inflammation major clinical study male medical research skin ulcer smoking habit vascular disease
Subjects: QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 06:48
Last Modified: 21 Jun 2020 06:48

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