Ovarian cancer stem cells and targeted therapy

Keyvani, V. and Farshchian, M. and Esmaeili, S. A. and Yari, H. and Moghbeli, M. and Nezhad, S. R. K. and Abbaszadegan, M. R. (2019) Ovarian cancer stem cells and targeted therapy. Journal of Ovarian Research, 12 (1).

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Abstract

Background: Ovarian cancer has the highest ratio of mortality among gynecologic malignancies. Chemotherapy is one of the most common treatment options for ovarian cancer. However, tumor relapse in patients with advanced tumor stage is still a therapeutic challenge for its clinical management. Main body: Therefore, it is required to clarify the molecular biology and mechanisms which are involved in chemo resistance to improve the survival rate of ovarian cancer patients. Cancer stem cells (CSCs) are a sub population of tumor cells which are related to drug resistance and tumor relapse. Conclusion: In the present review, we summarized the recent findings about the role of CSCs in tumor relapse and drug resistance among ovarian cancer patients. Moreover, we focused on the targeted and combinational therapeutic methods against the ovarian CSCs. © 2019 The Author(s).

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Nezhad, S.-R.K.; Department of Biology, Faculty of Science, Shahid Chamran University of AhvazIran; email: kazemireza@yahoo.de
Uncontrolled Keywords: Cancer stem cell Detection Drug resistance Isolation Ovarian cancer ABC transporter CD133 antigen CD24 antigen CD34 antigen epithelial cell adhesion molecule Hermes antigen myeloid differentiation factor 88 stem cell factor receptor uvomorulin cancer cell destruction cancer combination chemotherapy cancer prognosis cancer recurrence cancer resistance cancer staging cell isolation diffusion weighted imaging enrichment culture hedgehog signaling human MAPK signaling molecularly targeted therapy nonhuman Notch signaling ovarian cancer cell line ovary cancer positron emission tomography-computed tomography priority journal Review signal transduction whole body MRI Wnt signaling
Subjects: WQ Obstetrics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 06:48
Last Modified: 21 Jun 2020 06:48
URI: http://eprints.mums.ac.ir/id/eprint/18457

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