Bacterial infections are associated with cardiovascular disease in Iran: A meta-analysis

Khademi, F. and Vaez, H. and Momtazi-Borojeni, A. A. and Majnooni, A. and Banach, M. and Sahebkar, A. (2019) Bacterial infections are associated with cardiovascular disease in Iran: A meta-analysis. Archives of Medical Science, 15 (4). pp. 902-911.

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Introduction: The present study aimed to assess the prevalence and association of various bacterial infections with cardiovascular disease (CVD) in Iran. Material and methods: An electronic search was performed using related keywords in the national and international databases up to June 30, 2017. Out of the 1807 articles found on the associations between bacterial infections and CVD, 20 relevant studies were selected for the meta-analysis. Results: The prevalence of bacterial infections was higher in case groups compared with the control groups. Odds ratios for assessing the association between Chlamydia pneumonia infection and CVD based on PCR, IgG and IgA tests were 7.420 (95 CI: 3.088–17.827), 3.710 (95 CI: 1.361–10.115) and 2.492 (95 CI: 1.305–4.756), respectively. Moreover, the calculated odds ratio for Mycoplasma pneumonia infection was 1.815 (95 CI: 0.973–3.386). For Helicobacter pylori infection, odds ratios based on IgG and IgA tests were 3.160 (95 CI: 1.957–5.102) and 0.643 (95 CI: 0.414–0.999), respectively. Conclusions: The present meta-analysis suggested that there was a significant association between H. pylori, C. pneumonia and M. pneumonia infections and CVD in Iran. These findings confirm the potential role of bacterial infections as predisposing factors for CVD. Copyright © 2019 Termedia & Banach

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Sahebkar, A.; Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical ScienceIran; email:
Uncontrolled Keywords: Bacterial infection Cardiovascular disease Iran Meta-analysis immunoglobulin A immunoglobulin G chlamydial pneumonia controlled study disease association disease predisposition Helicobacter infection human meta analysis Mycoplasma pneumonia prevalence Review serology systematic review
Subjects: QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 07:17
Last Modified: 21 Jun 2020 07:17

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