Review on plant antimicrobials: A mechanistic viewpoint

Khameneh, B. and Iranshahy, M. and Soheili, V. and Fazly Bazzaz, B. S. (2019) Review on plant antimicrobials: A mechanistic viewpoint. Antimicrobial Resistance and Infection Control, 8 (1).

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Microbial resistance to classical antibiotics and its rapid progression have raised serious concern in the treatment of infectious diseases. Recently, many studies have been directed towards finding promising solutions to overcome these problems. Phytochemicals have exerted potential antibacterial activities against sensitive and resistant pathogens via different mechanisms of action. In this review, we have summarized the main antibiotic resistance mechanisms of bacteria and also discussed how phytochemicals belonging to different chemical classes could reverse the antibiotic resistance. Next to containing direct antimicrobial activities, some of them have exerted in vitro synergistic effects when being combined with conventional antibiotics. Considering these facts, it could be stated that phytochemicals represent a valuable source of bioactive compounds with potent antimicrobial activities. © 2019 The Author(s).

Item Type: Article
Additional Information: Cited By :3 Export Date: 16 February 2020 Correspondence Address: Fazly Bazzaz, B.S.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: Antibiotic-resistant Antimicrobial activity Combination therapy Mechanism of action Natural products Phytochemicals ajoene alkaloid allicin allyl isothiocyanate ampicillin antibiotic agent antiinfective agent baicalein benzyl isothiocyanate berberine cefepime cefoperazone ciprofloxacin dictamnine erythromycin gentamicin isothiocyanic acid derivative phenethyl isothiocyanate phytochemical piperine porin reserpine resveratrol sanguinarine squalamine streptomycin sulforaphane tetracycline tobramycin unindexed drug antibacterial activity antibiofilm activity antibiotic resistance antibiotic sensitivity bacterial cell wall bacterial membrane bactericidal activity bacteriostatic activity drug mechanism drug potentiation drug structure drug targeting human minimum bactericidal concentration minimum inhibitory concentration nonhuman nucleic acid synthesis priority journal protein synthesis inhibition Review
Subjects: QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 07:16
Last Modified: 21 Jun 2020 07:16

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