Parenteral systems for statin delivery: A review

Korani, S. and Bahrami, S. and Korani, M. and Banach, M. and Johnston, T. P. and Sahebkar, A. (2019) Parenteral systems for statin delivery: A review. Lipids in Health and Disease, 18 (1).

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Abstract

The oral route of drug administration is the most common and convenient route for dosing statin drugs, and, in fact, most medications, because of ease of drug delivery, patient compliance, and cost-effectiveness. However, the oral administration of statin drugs has disadvantages such as hepatic first-pass metabolism and degradation within the gastrointestinal tract that limit their overall bioavailability. This review introduces several diverse non-oral delivery methods for the administration of statins. These alternative delivery systems and routes of administration are varied and are capable of improving the bioavailability and therapeutic efficacy of statin drugs. © 2019 The Author(s).

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Sahebkar, A.; Neurogenic Inflammation Research Center, Mashhad University of Medical SciencesIran; email: sahebkara@mums.ac.ir
Uncontrolled Keywords: Cholesterol Drug delivery Parenteral Statins alginic acid antilipemic agent carboxymethylcellulose dodecyl sulfate sodium hydroxymethylglutaryl coenzyme A reductase inhibitor mevinolin pitavastatin pravastatin rosuvastatin simvastatin buccal drug administration buccal mucosa colon drug delivery system cost effectiveness analysis drug absorption drug bioavailability drug delivery system drug elimination drug half life drug release first pass effect gastric floating drug delivery system gastrointestinal tract histopathology hyperlipidemia local drug delivery system mucoadhesive drug delivery system parenteral drug administration patient compliance pulsatile drug delivery system Review risk reduction tablet formulation therapy
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 07:19
Last Modified: 21 Jun 2020 07:19
URI: http://eprints.mums.ac.ir/id/eprint/18476

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