Optical coherence tomography angiography in best vitelliform macular dystrophy

Mirshahi, A. and Lashay, A. and Masoumi, A. and Abrishami, M. (2019) Optical coherence tomography angiography in best vitelliform macular dystrophy. Journal of Current Ophthalmology, 31 (4). pp. 442-445.

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Purpose: To report best vitelliform macular dystrophy (BVMD) with an intriguing pattern of vascular flow on optical coherence tomography angiography (OCTA). Methods: Four eyes of two patients with BVMD were evaluated. Complete ophthalmic examination including best corrected visual acuity (BCVA), spectral domain optical coherence tomography (SD-OCT), and OCTA were performed. Diagnosis was confirmed by electroretinography (ERG) and electrooculography (EOG) testing. Results: All eyes had the electrophysiologic confirmation of the BVMD. The first patient was 35 years old with BCVA of 20/20 and pseudohypopyon stage macular lesion in right eye (RE) and BCVA of 20/32 and vitelliruptive stage macular lesion in the left eye (LE). The second patient was 18 years old with BCVA of 20/25 and macular lesion in vitelliform stage in the RE and BCVA of 20/60 and choroidal neovascularization (CNV) in the LE. In all eyes, a distinct foveal avascular zone (FAZ) was not detectable in OCTA, with a bridging vessel in the FAZ. A dense subretinal capillary network compatible with CNV in the LE of second patient was observed. Conclusion: In our cases, we found bridging vessel in the FAZ, and it may be due to the effects of bestrophin on the calcium content and vascular endothelial growth factor (VEGF) secretion of the retinal pigment epithelium (RPE) cells. © 2019 Iranian Society of Ophthalmology

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Abrishami, M.; Khatam-al-Anbia Eye Hospital, Eye Research Center, Mashhad University of Medical Sciences, Qarani Blvd., Iran; email: mojtabaabrishami@yahoo.com
Uncontrolled Keywords: Best vitelliform macular dystrophy Bridging vessel Choroidal neovascularization Foveal avascular zone Optical coherence tomography angiography bevacizumab adult age related macular degeneration Article best corrected visual acuity case report clinical article electrooculography electroretinography exudate human observational study retina hemorrhage spectral domain optical coherence tomography subretinal fluid vitelliform macular degeneration young adult
Subjects: WW Ophthalmology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 08:05
Last Modified: 21 Jun 2020 08:05
URI: http://eprints.mums.ac.ir/id/eprint/18506

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