Genetics of recurrent pregnancy loss among Iranian population

Moghbeli, M. (2019) Genetics of recurrent pregnancy loss among Iranian population. Molecular Genetics and Genomic Medicine, 7 (9).

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Abstract

Background: Recurrent pregnancy loss (RPL) is one of the most common reproductive disorders which is defined as the occurrence of recurrent miscarriage before 24 weeks of gestation and is observed among 1–5 of women. Methods: Various factors are associated with RPL such as immunological disorders, maternal age, obesity, alcohol, chromosomal abnormality, endocrine disorders, and uterine abnormalities. About half of the RPL cases are related with chromosomal abnormalities. Therefore, RPL genetic tests are mainly limited to karyotyping. However, there is a significant proportion of RPL cases without any chromosomal abnormalities that can be related to the single-gene aberrations. Therefore, it is required to prepare a diagnostic panel of genetic markers besides karyotyping. Results: In the present review, we have summarized all the significant reported genes until now which are associated with RPL among Iranian women. We categorized all the reported genes based on their cellular and molecular functions in order to determine the molecular bases of RPL in this population. Conclusion: This review paves the way of introducing a population-based diagnostic panel of genetic markers for the first time among Iranian RPL cases. Moreover, this review clarifies the genetic and molecular bases of RPL in this population. © 2019 The Author. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Moghbeli, M.; Medical Genetics Research Center, Mashhad University of Medical SciencesIran; email: Meysammoghbeli@yahoo.com
Uncontrolled Keywords: abortion genetic Iran marker miscarriage recurrent pregnancy loss
Subjects: WQ Obstetrics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 09:13
Last Modified: 21 Jun 2020 09:13
URI: http://eprints.mums.ac.ir/id/eprint/18516

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