ErbB1 and ErbB3 co-over expression as a prognostic factor in gastric cancer

Moghbeli, M. and Makhdoumi, Y. and Soltani Delgosha, M. and Aarabi, A. and Dadkhah, E. and Memar, B. and Abdollahi, A. and Abbaszadegan, M. R. (2019) ErbB1 and ErbB3 co-over expression as a prognostic factor in gastric cancer. Biological research, 52 (1). p. 2.

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Abstract

BACKGROUND: Epidermal growth factor receptor family members such as ErbB1 and ErbB3 are involved in tumor progression and metastasis. Although, there are various reports about the prognostic value of EGFR members separately in gastric cancer, there is not any report about the probable correlation between ErbB1 and ErbB3 co-expression and gastric cancer prognosis. In present study, we assessed the correlation between ErbB1 and ErbB3 co-overexpression (in the level of mRNA and protein expression) and gastric cancer prognosis for the first time. METHODS: ErbB1 and ErbB3 expressions were analyzed by immunohistochemistry and real-time PCR in 50 patients with gastric cancer. Parametric correlations were done between the ErbB1 and ErbB3 expression and clinicopathological features. Multivariate and logistic regression analyses were also done to assess the roles of ErbB1 and ErbB3 in tumor prognosis and survival. RESULTS: There were significant correlations between ErbB1/ErbB3 co-overexpression and tumor size (p = 0.026), macroscopic features (p < 0.05), tumor differentiation (p < 0.05), stage of tumor (p < 0.05), and recurrence (p < 0.05). Moreover, ErbB1/ErbB3 co-overexpression may predict the survival status of patients (p < 0.05). CONCLUSION: ErbB1 and ErbB3 co-overexpression is accompanied with the poor prognosis and can be used efficiently in targeted therapy of gastric cancer patients.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020
Uncontrolled Keywords: EGFR Gastric cancer HER3 Prognosis Targeted therapy epidermal growth factor receptor 3 ERBB3 protein, human tumor marker adult aged female gene expression regulation genetics human immunohistochemistry male metabolism middle aged mortality pathology proto oncogene real time polymerase chain reaction stomach tumor survival rate very elderly Aged, 80 and over Biomarkers, Tumor Gene Expression Regulation, Neoplastic Genes, erbB Genes, erbB-1 Humans Real-Time Polymerase Chain Reaction Receptor, ErbB-3 Stomach Neoplasms
Subjects: QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 09:13
Last Modified: 21 Jun 2020 09:13
URI: http://eprints.mums.ac.ir/id/eprint/18517

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