Folate-modified and curcumin-loaded dendritic magnetite nanocarriers for the targeted thermo-chemotherapy of cancer cells

Montazerabadi, A. and Beik, J. and Irajirad, R. and Attaran, N. and Khaledi, S. and Ghaznavi, H. and Shakeri-Zadeh, A. (2019) Folate-modified and curcumin-loaded dendritic magnetite nanocarriers for the targeted thermo-chemotherapy of cancer cells. Artificial Cells, Nanomedicine and Biotechnology, 47 (1). pp. 330-340.

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Abstract

A novel multifunctional nanoplatform constructed from methoxy-PEGylated poly(amidoamine) (PAMAM) generation 3 dendrimers with superparamagnetic iron oxide nanoparticles (SPIONs) entrapped in their core, containing curcumin as the payload drug and folic acid (folate) as the targeting ligand (abbreviated as FA-mPEG-PAMAM G3-CUR@SPIONs), is presented in this study. SPIONs entrapped in the core of the nanocomplex may act as a hyperthermia agent and generate localized heat upon excitation with an alternating magnetic field (AMF), thus enabling a thermo-chemotherapy strategy for cancer treatment. Accordingly, the cytotoxic effect and the mode of cell death triggered by the nanocomplex in combination with AMF were evaluated on two different cancer cell lines with various folate receptor (FR) expression levels, including KB nasopharyngeal cancer cells overexpressing FRs as the model and MCF-7 breast cancer cells with low level of FRs as the blank sample. The obtained results showed that KB cell death was greater than the cell death observed in MCF-7 cells. Moreover, a majority of cell death in both cell lines were related to apoptosis when the folate-modified nanocomplex was used instated of the non-folate-modified nanocomplex. Therefore, functionalizing the nanocomplex with folate modulated the response to thermo-chemotherapy by shifting the cell death pathways toward apoptosis. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: Cited By :9 Export Date: 16 February 2020 Correspondence Address: Shakeri-Zadeh, A.; Medical Physics Research Center, Mashhad University of Medical SciencesIran; email: shakeriz@iums.ac.ir
Uncontrolled Keywords: curcumin Dendrimer folic acid magnetic nanoparticles thermo-chemotherapy Cell culture Cell death Chemotherapy Dendrimers Diseases Hyperthermia therapy Iron oxides Magnetite Nanomagnetics Nanoparticles Organic acids Alternating magnetic field Cell-death pathways Folic acids Magnetic nano-particles MCF-7 breast cancer cells Nasopharyngeal cancer Superparamagnetic iron oxide nanoparticles Targeted drug delivery carboxylic acid folate receptor macrogol magnetite nanoparticle nanocarrier polyamidoamine superparamagnetic iron oxide nanoparticle drug carrier PAMAM Starburst apoptosis Article cancer chemotherapy cell viability comparative study conjugation controlled study cytotoxicity drug release gene overexpression high performance liquid chromatography human human cell KB cell line magnetic field magnetic separation MCF-7 cell line nanoencapsulation nanofabrication nanopharmaceutics protein expression chemistry temperature Drug Carriers Drug Liberation Humans Magnetite Nanoparticles MCF-7 Cells
Subjects: QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 09:13
Last Modified: 21 Jun 2020 09:13
URI: http://eprints.mums.ac.ir/id/eprint/18539

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